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Developmental consequences of children born from mothers with telbivudine treatment during late pregnancy: A prospective study with 3-year follow-up.

Author: CaoWeihua, CaoXiuzhen, LiMinghui, SunFangfang, WanGang, WangYing, XieYao, YiWei, ZengZhan, ZhangYing

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the long-term effects of telbivudine (LdT) exposure during pregnancy on infant neurological development. Infants born to mothers who received LdT in the third trimester for hepatitis B virus prevention showed slightly better gross motor skills but slightly poorer adaptive skills at 36 months compared to infants whose mothers did not receive LdT. Further research is needed to understand the long-term implications of prenatal LdT exposure on neurological development.
Paper Details　
Original Abstract of the Article :
We prospectively investigated the neurological development in infants born from mothers treated with telbivudine (LdT) in the third trimester for prevention of hepatitis B virus (HBV) mother-to-infant transmission. Mothers with high HBV load were assigned to either the LdT group (<i>n</i> =&#160;81,...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205043/

データ提供：米国国立医学図書館（NLM）

Investigating the Developmental Impacts of Telbivudine on Infants

This research investigates the effects of telbivudine (LdT), a medication given to pregnant women to prevent hepatitis B virus (HBV) transmission to their babies, on infant development. The study, using a prospective approach, compared infants born to mothers who received LdT during late pregnancy (the LdT group) with those born to untreated mothers (the Control group). The researchers used the Gesell Developmental Schedule to assess the infants' physical and neurological development over a period of 36 months.

Significant Differences in Motor and Adaptive Development

While the LdT group showed similar developmental scores to the Control group at 12 months, a noticeable difference emerged at 36 months. Infants in the LdT group had higher mean scores for gross motor skills and lower scores for adaptive skills compared to the Control group. These findings suggest that LdT exposure during pregnancy might have a lasting impact on infant neurological development.

Implications for Maternal and Infant Health

This study provides important insights into the potential long-term effects of prenatal LdT exposure on infant development. While LdT is an effective treatment for preventing HBV transmission, its impact on infant development raises concerns. Further research is needed to understand the mechanisms underlying these developmental differences and to explore strategies for mitigating potential risks.

Dr.Camel's Conclusion

This study highlights the importance of considering the potential long-term consequences of medications used during pregnancy. Think of it like this: a camel trekking across the desert needs to make sure it's well-prepared for the journey. Similarly, mothers should be well-informed about the potential effects of medications they take during pregnancy, ensuring the best possible start for their little ones.

Date :
  1. Date Completed 2022-01-26
  2. Date Revised 2022-01-26
Further Info :

Pubmed ID

34120564

DOI: Digital Object Identifier

PMC8205043

Related Literature

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・Effects of telbivudine
SNS
PICO Info
in preparation
Languages

English

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