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Tyrosine Kinase Inhibitor Sunitinib Delays Platelet-Induced Coagulation: Additive Effects of Aspirin.

Author: AartsMaureen J B, BaatenConstance C F M J, CampelloElena, EbleJohannes A, FernándezDelia I, HeemskerkJohan W M, KuijpersMarijke J E, PetersLinsey J F, SimioniPaolo, SpieziaLuca, TullemansBibian M E, VeningaAlicia, van der MeijdenPaola E J, van der VorstEmiel P C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of sunitinib, a multitarget tyrosine kinase inhibitor, on thrombus formation under different conditions, including coagulating conditions. It also examined the synergistic effects of sunitinib and aspirin on thrombus and fibrin formation.
Paper Details　
Original Abstract of the Article :
Sunitinib is a multitarget tyrosine kinase inhibitor (TKI) used for cancer treatment. In platelets, sunitinib affects collagen-induced activation under noncoagulating conditions. We investigated (1) the effects of sunitinib on thrombus formation induced by other TK-dependent receptors, and (2) the e...See full text at original site
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引用元：
https://doi.org/10.1055/s-0041-1730312

データ提供：米国国立医学図書館（NLM）

Sunitinib and Aspirin: A Double-Edged Sword in Cancer Treatment

This study examines the effects of sunitinib, a tyrosine kinase inhibitor (TKI) used for cancer treatment, on platelet function, particularly in the context of aspirin co-administration. It's like exploring the complex interplay of medications in the fight against cancer, seeking to understand the potential benefits and risks associated with sunitinib and aspirin.

Sunitinib's Impact on Platelet Function: A Tightrope Walk

The study reveals that sunitinib can delay platelet-induced coagulation, suggesting a potential risk of increased bleeding in patients receiving this medication. It's like walking a tightrope between the benefits of cancer treatment and the potential risks associated with sunitinib's impact on platelet function.

Sunitinib and Aspirin: A Balancing Act

The research emphasizes the need for careful consideration when co-administering sunitinib and aspirin, acknowledging the potential for additive effects on bleeding risk. It's like a delicate balancing act, ensuring that the benefits of each medication outweigh the potential risks.

Dr. Camel's Conclusion

This study underscores the importance of carefully weighing the potential benefits and risks associated with sunitinib and aspirin co-administration. It's like navigating a delicate path through the desert of cancer treatment, understanding the complex interplay of medications and their potential impact on platelet function and overall health. This research provides valuable insights for managing cancer treatment and ensuring patient safety.
Date :
  1. Date Completed 2022-03-22
  2. Date Revised 2022-03-22
Further Info :

Pubmed ID

34130349

DOI: Digital Object Identifier

10.1055/s-0041-1730312

Related Literature

Article Analysis
・Effects of sunitinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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