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Pharmacoepigenomics circuits induced by a novel retinoid-polyamine conjugate in human immortalized keratinocytes.
Author: AnastasakisDimitrios, DrainasDenis, GrafanakiKaterina, KontosChristos K, KorfiatiAigli, KyriakopoulosGeorge, MagoulasGeorge, MavroudiSeferina, PapaioannouDionissios, ScorilasAndreas, SkeparniasIlias, StathopoulosConstantinos, TheofilatosKonstantinos
Original Abstract of the Article :
Retinoids are widely used in diseases spanning from dermatological lesions to cancer, but exhibit severe adverse effects. A novel all-trans-Retinoic Acid (atRA)-spermine conjugate (termed RASP) has shown previously optimal in vitro and in vivo anti-inflammatory and anticancer efficacy, with undetect...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1038/s41397-021-00241-9
データ提供:米国国立医学図書館(NLM)
Retinoids: A Skin Savior with a Twist
We're always looking for ways to improve our skin health, and retinoids have been a popular choice for treating a variety of skin conditions, from acne to wrinkles. But, like a camel navigating a treacherous desert, retinoids can sometimes have unpleasant side effects. This research delves into the intriguing world of pharmacoepigenomics, focusing on the exciting potential of a new retinoid derivative called RASP. The study employed a strategy similar to a wise traveler carefully selecting their path through a vast desert. Using a combination of miRNA and gene expression analysis, researchers investigated the impact of RASP on human keratinocytes. The findings revealed that RASP, like a gentle oasis in the desert, possesses the beneficial effects of retinoids while minimizing the potential for negative side effects.
RASP: A New Hope for Skin Health
The research demonstrates that RASP is a promising candidate for treating skin disorders, including skin cancer. This is a significant finding, as RASP has shown promising results in its ability to modulate cellular processes involved in skin health. It has the potential to be a game-changer in dermatological treatments.
RASP's Potential Impact on Skin Care
RASP's effectiveness and safety profile suggest that it could become a valuable addition to the skin care toolbox. Think of RASP as a refreshing spring in the desert, offering a new approach to skin care. As this research sheds light on the potential of RASP, we can envision a future where personalized skin care regimens are tailored to individual needs, offering targeted solutions for healthy, glowing skin.
Dr. Camel's Conclusion
This study, like a caravan journeying through the desert, unveils the potential of RASP as a novel retinoid derivative with improved properties, offering a beacon of hope for safer and more effective skin treatments.
Date :
- Date Completed 2022-03-10
- Date Revised 2023-02-03
Further Info :
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