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Obeticholic Acid and Fibrates in Primary Biliary Cholangitis: Comparative Effects in a Multicentric Observational Study.

Author: AlbillosAgustín, AndradeRaúl J, ArencibiaAna, BerenguerMarina, CasadoMarta, ChahriNadia, De la CruzGema, DiagoMoises, EstevezPamela, Fernandez-BonillaEva, Fernández-RodriguezConrado M, Ferre-AracilCarlos, FábregaEmilio, Gallego-MoyaAdolfo, González-SantiagoJesús M, Gómez-CamareroJudith, Gómez-DomínguezElena, Hernández-GuerraManuel, HijonaLander, HortaDiana, MolinaEsther, MorillasRosa M, ParésAlbert, Pérez-MedranoIndhira M, ReigAnna, Romero-GomezManuel, SalaMargarita, SuárezFrancisco, VargasVictor, VergaraMercedes, Álvarez-NavascuésCarmen

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study assessed the effectiveness and adverse events of obeticholic acid and fibrates therapy in patients with primary biliary cholangitis.
Paper Details　
Original Abstract of the Article :
Obeticholic acid (OCA) and fibrates therapy results in biochemical improvement in placebo-controlled trials in patients with primary biliary cholangitis and insufficient response to ursodeoxycholic acid. There is scarce information outside of clinical trials. Therefore, we have assessed the effectiv...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/34158466

データ提供：米国国立医学図書館（NLM）

Obeticholic Acid and Fibrates in Primary Biliary Cholangitis: A Comparative Study

Primary biliary cholangitis (PBC), a chronic liver disease, often requires treatment with ursodeoxycholic acid (UDCA). This observational study compares the effectiveness of obeticholic acid (OCA) and fibrates therapy in patients with PBC who have an insufficient response to UDCA. The study found that both OCA and fibrates therapy resulted in biochemical improvement, highlighting the potential of these alternative treatment options for patients with PBC.

Exploring Treatment Options for PBC: A Comparative Analysis

This study offers a comparative analysis of OCA and fibrates therapy in patients with PBC who have not responded adequately to UDCA. Similar to a camel seeking alternative routes through a challenging desert terrain, this study explores different treatment options for PBC, providing valuable insights for clinicians and patients alike. The findings suggest that both OCA and fibrates therapy may offer benefits for patients with PBC, potentially improving liver function and overall well-being.

Navigating Treatment Decisions for PBC: Understanding the Options

The study underscores the importance of understanding the various treatment options available for patients with PBC. It highlights the potential benefits of OCA and fibrates therapy, particularly for those who have not responded well to UDCA. As always, it is essential to discuss treatment options with healthcare professionals to make informed decisions based on individual needs and medical history.

Dr. Camel's Conclusion

This observational study provides valuable insights into the effectiveness of OCA and fibrates therapy in patients with PBC who have an insufficient response to UDCA. The findings suggest that these alternative treatment options may offer promising benefits for patients, potentially improving liver function and overall well-being. Further research is needed to confirm these findings and to explore the long-term effects of these therapies.

Date :
  1. Date Completed 2021-11-24
  2. Date Revised 2021-12-14
Further Info :

Pubmed ID

34158466

DOI: Digital Object Identifier

00000434-202111000-00020

Related Literature

Article Analysis
・Effects of obeticholic acid
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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