Diffusion basis spectrum imaging measures anti-inflammatory and neuroprotective effects of fingolimod on murine optic neuritis.

Author: CrossAnne H, GeorgeAjit, LaiShengsheng, LinTsen-Hsuan, SongChunyu, SongSheng-Kwei, SunPeng, WallendorfMichael, YangRuimeng, YeZezhong, ZhanJie

Paper Details 
Original Abstract of the Article :
To prospectively determine whether diffusion basis spectrum imaging (DBSI) detects, differentiates and quantitates coexisting inflammation, demyelination, axonal injury and axon loss in mice with optic neuritis (ON) due to experimental autoimmune encephalomyelitis (EAE), and to determine if DBSI acc...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240023/

データ提供:米国国立医学図書館(NLM)

Diffusion Basis Spectrum Imaging for Optic Neuritis

Optic neuritis, an inflammation of the optic nerve, can lead to vision loss. This study explored the use of diffusion basis spectrum imaging (DBSI) to assess the effectiveness of fingolimod, a medication used to treat optic neuritis. The researchers examined the ability of DBSI to detect and quantify inflammation, demyelination, axonal injury, and axon loss in mice with optic neuritis. The study found that DBSI could effectively measure the effects of fingolimod on underlying pathology.

DBSI: A Tool for Understanding Optic Neuritis

This study highlights the potential of DBSI as a powerful tool for assessing the effectiveness of treatments for optic neuritis. This is like having a special microscope that allows you to see the intricate details of the desert landscape. The study showed that DBSI can detect and quantify different pathological processes within the optic nerve, providing valuable information for researchers and clinicians.

Hope for Vision Loss

The findings of this study suggest that DBSI may play a crucial role in developing and monitoring treatments for optic neuritis. This is like finding a hidden oasis in the desert, offering hope for those facing vision loss. It's a reminder that even in the face of complex neurological conditions, there are advancements in technology and research that can provide valuable insights and potential solutions.

Dr.Camel's Conclusion

The desert of neurological research is vast and complex. This study sheds light on a new tool, DBSI, that offers a more detailed understanding of optic neuritis. It's a reminder that the quest for knowledge continues, and new discoveries can provide hope for those affected by neurological disorders. This is a fascinating journey of exploration in the world of medicine.

Date :
  1. Date Completed 2021-09-13
  2. Date Revised 2022-10-15
Further Info :

Pubmed ID

34166868

DOI: Digital Object Identifier

PMC8240023

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Languages

English

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