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Anti-Inflammatory and Mineralization Effects of Bromelain on Lipopolysaccharide-Induced Inflammation of Human Dental Pulp Cells.
Author: HongJoo-Hyun, HwangYun-Chan, ImYeong-Gwan, KimMi-Ra, LeeBin-Na, MinKyung-San, OhWon-Mann
Original Abstract of the Article :
<i>Background and Objectives</i>: Bromelain is a mixture of protease obtained from pineapple fruits or stems. Even though the biological mechanism of action of bromelain has not been completely understood, it is well known that bromelain possesses anticancer, anti-inflammatory and immunomodulatory ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227231/
データ提供:米国国立医学図書館(NLM)
Bromelain: A Potential Oasis in the Desert of Dental Pulp Inflammation
In the complex landscape of oral health, inflammation of the dental pulp is a common challenge. This study explores the potential of bromelain, a protease derived from pineapples, to combat this inflammation. The researchers investigated the anti-inflammatory effects of bromelain on lipopolysaccharide (LPS)-induced inflammation in human dental pulp cells (hDPCs) using a variety of laboratory techniques, including Western blotting, immunofluorescence staining, and enzyme-linked immunosorbent assay. They found that bromelain significantly reduced the expression of inflammatory cytokines, including interleukin-1β, interleukin-6, and interleukin-8, in hDPCs. Furthermore, bromelain inhibited the activation of key signaling pathways, such as NF-κB and MAPK, which are crucial for inflammatory responses. These findings suggest that bromelain might have the potential to be used for regenerative endodontics, including vital pulp therapy.
Bromelain: A Powerful Anti-Inflammatory Agent
This study offers a glimmer of hope in the desert of dental inflammation, demonstrating bromelain's potential to effectively reduce inflammation in dental pulp cells. The study's findings indicate that bromelain not only suppresses the production of inflammatory cytokines but also regulates the signaling pathways that drive inflammation. This remarkable ability could lead to novel treatments for dental pulp inflammation, potentially reducing the need for invasive procedures.
Harnessing the Power of Pineapple: A Natural Approach to Dental Health
The study suggests that bromelain, a naturally occurring enzyme found in pineapples, could hold the key to combating dental pulp inflammation. This finding opens the door to exploring natural, less invasive approaches to dental health. While further research is needed to confirm the effectiveness and safety of bromelain for treating dental pulp inflammation, this study provides a promising starting point for exploring new avenues for oral health care.
Dr.Camel's Conclusion
This study is a testament to the power of nature, demonstrating the potential of bromelain to quench the flames of dental pulp inflammation. It offers a promising glimpse into the future of oral health care, potentially revolutionizing the way we treat dental problems.
Date :
- Date Completed 2021-07-05
- Date Revised 2021-07-05
Further Info :
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