Paper Details

  1. Home
  2. Paper Details

Estrogen-Like Effect of Mitotane Explained by Its Agonist Activity on Estrogen Receptor-α.

Author: AbateAndrea, BerrutiAlfredo, CosentiniDeborah, GangemiFabrizio, GiacopuzziEdoardo, GrisantiSalvatore, LaganàMarta, RossiniElisa, SigalaSandra, TamburelloMariangela

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the interaction between mitotane, a drug used to treat adrenocortical carcinoma, and estrogen receptor-α (ER-α). The study found that mitotane directly binds and activates ER-α, explaining the estrogenic-like side effects observed in patients.
Paper Details　
Original Abstract of the Article :
Mitotane is the cornerstone of medical treatment of adrenocortical carcinoma. Estrogenic-like side effects frequently occur in patients, and previous studies explored the chemical nature of the interaction between estrogen receptor-α (ER-α) and toxic compounds, including the DDD derivatives. We used...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235434/

データ提供：米国国立医学図書館（NLM）

Mitotane's Estrogenic Side Effects: Unveiling the Mechanism

Mitotane is a crucial medication for treating adrenocortical carcinoma. However, patients often experience estrogen-like side effects. This study delves into the molecular mechanisms underlying this phenomenon, revealing how mitotane interacts with the estrogen receptor-α (ER-α).

Mitotane: A Molecular Mimic

Through a combination of molecular modeling and cell-based experiments, the study shows that mitotane binds to ER-α in a similar way as 17β-estradiol, the natural hormone. This binding triggers a cascade of events that lead to estrogen-like effects. It's like a chameleon changing its color to blend in, in this case, mitotane mimicking the actions of a key hormone!

Understanding the Side Effects

This research sheds light on the mechanism behind mitotane's estrogenic side effects, paving the way for potential strategies to mitigate them. It reminds us that the effects of drugs can be complex and that even the most promising medications might come with unexpected side effects. It's a stark reminder of the intricate dance between chemicals and our bodies, much like the complex dance patterns of a sandstorm.

Dr.Camel's Conclusion

Like a desert explorer carefully mapping a new terrain, this research illuminates the complex interactions between drugs and the body. The findings offer valuable insights into the estrogenic side effects of mitotane, helping us to better understand and potentially manage these effects in the future.

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-07-05
Further Info :

Pubmed ID

34208714

DOI: Digital Object Identifier

PMC8235434

Related Literature

Article Analysis
・Side Effects of mitotane
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.