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The Impact of Marijuana on Antidepressant Treatment in Adolescents: Clinical and Pharmacologic Considerations.

Author: PoweleitEthan A, RamseyLaura B, SarangdharMayur, StrawnJeffrey R, VaughnSamuel E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the interactions between cannabinoids and selective serotonin reuptake inhibitors (SSRIs) in youth. It found that cannabinoids can increase SSRI levels in adolescents and coadministration of CBD and CYP2C19-metabolized SSRIs increases the risk of certain side effects.
Paper Details　
Original Abstract of the Article :
The neuropharmacology of marijuana, including its effects on selective serotonin reuptake inhibitor (SSRI)/antidepressant metabolism and the subsequent response and tolerability in youth, has received limited attention. We sought to (1) review clinically relevant pharmacokinetic (PK) and pharmacodyn...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307883/

データ提供：米国国立医学図書館（NLM）

The Impact of Marijuana on Antidepressant Treatment in Adolescents

Navigating the complexities of mental health, especially in adolescents, can be tricky. This research explores the interaction between marijuana and antidepressant treatment, specifically focusing on the impact of cannabinoids on selective serotonin reuptake inhibitors (SSRIs). The researchers use pharmacokinetic (PK) and pharmacodynamic (PD) models to understand how cannabinoids affect SSRI levels and potential side effects. This study sheds light on the crucial need for open communication between patients and healthcare providers regarding cannabis use.

Unraveling the Complex Interaction

The study reveals a potential for significant interactions between cannabinoids and SSRIs. The analysis shows that certain cannabinoids can increase the concentration of SSRIs in the body, which could lead to increased risk of certain side effects. This highlights the importance of careful monitoring and open dialogue between healthcare providers and patients about cannabis use.

Navigating the Labyrinth of Drug Interactions

When it comes to mental health, it’s crucial to understand the potential impacts of different substances, especially in adolescents. Think of it like a camel navigating a labyrinth of sand dunes – a wrong turn could lead to getting lost. This research provides valuable insights into the complex interplay between cannabinoids and antidepressants. By understanding these interactions, we can make informed decisions about treatment and ensure the safety and well-being of our young people.

Dr.Camel's Conclusion

This research sheds light on the importance of being mindful of the potential interactions between cannabinoids and antidepressants. Open communication between patients and healthcare providers is essential for safe and effective treatment. Just as a wise camel always seeks clear paths through the desert, we must carefully consider the potential hazards of drug interactions, especially in adolescents.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-03-23
Further Info :

Pubmed ID

34209709

DOI: Digital Object Identifier

PMC8307883

SNS
PICO Info
in preparation
Languages

English

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