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Exploiting polypharmacology to dissect host kinases and kinase inhibitors that modulate endothelial barrier integrity.

Author: DankwaSelasi, DolsMary-Margaret, GlennonElizabeth K K, KainHeather S, KaushanskyAlexis, SmithJoseph D, WeiLing

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates kinase inhibitors for promoting endothelial barrier integrity following inflammatory damage. It uses a kinase regression approach to identify potential barrier-regulating kinases and their mechanisms of action.
Paper Details　
Original Abstract of the Article :
Kinase inhibitors are promising drugs to stabilize the endothelial barrier following inflammatory damage. However, our limited knowledge of how kinase signaling activates barrier-restorative pathways and the complexity of multi-target drugs have hindered drug discovery and repurposing efforts. Here,...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/34216546

データ提供：米国国立医学図書館（NLM）

Endothelial Barrier Integrity: Unveiling the Secrets of a Fragile Desert

This study delves into the fascinating world of endothelial barrier integrity and explores the potential of kinase inhibitors to restore this barrier after inflammatory damage. Imagine a vast desert with a fragile, leaking oasis – that's what a damaged endothelial barrier is like. This research investigates how kinase signaling influences the barrier and explores the potential of kinase inhibitors to mend this fragile ecosystem.

Kinase Inhibitors: A Powerful Tool for Barrier Repair

The study screened 28 kinase inhibitors and identified multiple inhibitors that promote endothelial barrier integrity. It's like discovering a powerful tool that can repair the leaky walls of the oasis, restoring its balance and resilience. This research highlights the importance of understanding the complex interplay of kinases in regulating barrier integrity and the potential of kinase inhibitors to restore this vital function.

Endothelial Barrier: A Fragile Ecosystem in Need of Protection

The study emphasizes the importance of maintaining endothelial barrier integrity for overall health and well-being. It's like ensuring the oasis remains a thriving hub of life, offering essential resources for survival. This research sheds light on the complex mechanisms that govern barrier integrity and the potential of kinase inhibitors to protect this delicate ecosystem.

Dr.Camel's Conclusion

This study explores the intricate world of endothelial barrier integrity and the potential of kinase inhibitors to restore this barrier after inflammatory damage. It's like uncovering a hidden spring of knowledge in the desert, revealing the secrets of this delicate ecosystem. The research highlights the importance of understanding kinase signaling and the potential of kinase inhibitors to protect and repair this vital barrier. The journey to understand and restore endothelial barrier integrity continues, and this study provides valuable insights into this fascinating area of research.

Date :
  1. Date Completed 2022-01-20
  2. Date Revised 2022-12-17
Further Info :

Pubmed ID

34216546

DOI: Digital Object Identifier

NIHMS1721840

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Languages

English

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