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Pyridostigmine ameliorates preeclamptic features in pregnant rats by inhibiting tumour necrosis factor-α synthetsis and antagonizing tumour necrosis factor-α-related effects.

Author: AliMd Ahasan, Issotina ZibrilaAbdoulaye, KangYuming, LiChunfang, LiuJinjun, LiuKaili, OseiJames Ampofo, SunYuyao, WangZheng, ZafarSalman

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Pyridostigmine (PYR) is an anti-inflammatory drug that has been shown to reduce blood pressure in preeclampsia models. This study investigates the potential therapeutic effects of PYR in preeclampsia models, specifically its effects on blood pressure and other pathological features.
Paper Details　
Original Abstract of the Article :
Preeclampsia is a hypertensive disorder of pregnancy marked by an excessive inflammatory response. The anti-inflammatory effect of pyridostigmine (PYR) was previously reported; however, its role in hypertensive pregnancies remains unclear. We hypothesized that PYR could attenuate increased blood pre...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/34232157

データ提供：米国国立医学図書館（NLM）

Pyridostigmine and Preeclampsia

This study investigates the potential of pyridostigmine (PYR), an anticholinesterase drug, to alleviate the symptoms of preeclampsia, a potentially dangerous condition that affects pregnant women. The researchers focused on the anti-inflammatory properties of PYR and its potential to reduce blood pressure and other preeclampsia-related features in a rat model. They found that PYR may alleviate preeclamptic features by inhibiting tumor necrosis factor-α synthesis and antagonizing its effects.

A Promising Avenue for Preeclampsia Management

This research explores a novel approach to managing preeclampsia, suggesting that PYR could potentially offer a new treatment option. The study's findings warrant further investigation in human clinical trials to confirm the safety and efficacy of PYR in treating preeclampsia.

Navigating Pregnancy with Preeclampsia

Preeclampsia can be a serious health concern during pregnancy. While more research is needed to fully understand the potential benefits of PYR, the study's findings offer hope for new therapeutic strategies. It's essential to work closely with your healthcare provider to manage preeclampsia effectively and ensure a safe and healthy pregnancy.

Dr.Camel's Conclusion

The desert of pregnancy can sometimes be a treacherous landscape. This study offers a glimmer of hope, exploring the potential of pyridostigmine to alleviate the challenges of preeclampsia. It is a testament to the ongoing quest for innovative solutions to improve maternal and fetal health.
Date :
  1. Date Completed 2021-10-26
  2. Date Revised 2021-11-03
Further Info :

Pubmed ID

34232157

DOI: Digital Object Identifier

00004872-202109000-00006

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・Effects of pyridostigmine
SNS
PICO Info
in preparation
Languages

English

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