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Inflammatory myofibroblastic tumor: molecular landscape, targeted therapeutics, and remaining challenges.

Author: CasanovaMichela, FerrariAndrea, FordhamAshleigh, MahajanPriya, TrahairToby, VenkatramaniRajkumar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the molecular characteristics, evolution of targeted therapies, and remaining challenges in the management of inflammatory myofibroblastic tumor (IMT), a rare mesenchymal tumor.
Paper Details　
Original Abstract of the Article :
Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor of intermediate malignant potential that predominantly affects children, adolescents and young adults. IMT has a predilection for the lung, abdomen, pelvis, and retroperitoneum, however, can affect any part of the body. IMT is typi...See full text at original site
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引用元：
https://doi.org/10.1016/j.currproblcancer.2021.100768

データ提供：米国国立医学図書館（NLM）

Navigating the Shifting Sands of Inflammatory Myofibroblastic Tumor (IMT)

In the vast landscape of oncology, inflammatory myofibroblastic tumor (IMT) stands out as a rare and complex entity. This mesenchymal tumor, with intermediate malignant potential, predominantly affects children and young adults. While IMT typically presents as localized, it can manifest in various parts of the body, making treatment a challenging journey across the diverse terrains of oncology.

This review, published in the journal Frontiers in Oncology, delves into the molecular landscape of IMT, shedding light on the genetic alterations that drive its development. The authors explore the evolution of targeted therapies, focusing on the role of tyrosine kinase inhibitors in managing these tumors.

Mapping the Molecular Landscape: A Journey of Discovery

This comprehensive review highlights the diverse molecular characteristics of IMT, emphasizing the significance of genetic rearrangements involving genes such as ALK, ROS1, PDGFRβ, RET, and NTRK. This newfound understanding opens up avenues for developing personalized treatment strategies tailored to the specific molecular profile of each individual tumor.

A Glimmer of Hope: Navigating the Desert of IMT

This research offers a beacon of hope for patients with IMT. By understanding the molecular landscape of this rare tumor, researchers can develop targeted therapies that effectively address the underlying genetic drivers of the disease. These new approaches, like finding a hidden oasis in the desert, could significantly improve treatment outcomes and enhance the quality of life for patients with IMT.

Dr.Camel's Conclusion

This review provides a valuable resource for oncologists and researchers seeking to understand and effectively treat IMT. It highlights the importance of a molecularly-driven approach to personalized medicine, offering hope for improved treatment options and outcomes for patients with this rare and challenging tumor.

Date :
  1. Date Completed 2021-12-31
  2. Date Revised 2021-12-31
Further Info :

Pubmed ID

34244015

DOI: Digital Object Identifier

10.1016/j.currproblcancer.2021.100768

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