Insights into the mechanism by which atropine inhibits myopia: evidence against cholinergic hyperactivity and modulation of dopamine release.

Author: AshbyRegan, KaroutaCindy, KellyTamsin, MorganIan, ThomsonKate

Paper Details 
Original Abstract of the Article :
The ability of the muscarinic cholinergic antagonist atropine to inhibit myopia development in humans and animal models would suggest that cholinergic hyperactivity may underlie myopic growth. To test this, we investigated whether cholinergic agonists accelerate ocular growth rates in chickens. Furt...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293064/

データ提供:米国国立医学図書館(NLM)

Atropine: Delving Deeper into its Antimyopic Mechanism

Myopia, or nearsightedness, is a prevalent eye condition affecting millions worldwide. This study investigates the mechanism by which atropine, a muscarinic cholinergic antagonist, inhibits myopia development. The researchers challenge the hypothesis that cholinergic hyperactivity underlies myopic growth and explore the potential role of dopamine modulation in atropine's antimyopic effects. The findings suggest that atropine's antimyopic action may not be directly related to cholinergic hyperactivity but could involve downstream modulation of dopamine levels.

Atropine: A Complex Mechanism of Action

This study's findings challenge the traditional understanding of atropine's antimyopic mechanism. By exploring the potential role of dopamine modulation, the researchers open a new avenue for investigating the complex interplay of neurotransmitters in myopia development. This research holds important implications for the development of new and more effective treatments for myopia.

Myopia: A Journey Through the Lens of Vision

Myopia, like a mirage in the desert, can distort our perception of the world. This study offers valuable insights into the complex mechanisms underlying this condition. Understanding the role of dopamine modulation could lead to new approaches for preventing and treating myopia, allowing individuals to navigate their visual journeys with greater clarity and focus.

Dr.Camel's Conclusion

This research delves into the intriguing mechanism of atropine's antimyopic effects, suggesting that its action might not solely be attributed to cholinergic hyperactivity but could involve dopamine modulation. This study opens new avenues for understanding the complex interplay of neurotransmitters in myopia development, potentially leading to more effective treatment strategies.

Date :
  1. Date Completed 2021-12-09
  2. Date Revised 2022-07-31
Further Info :

Pubmed ID

34302355

DOI: Digital Object Identifier

PMC9293064

Related Literature

SNS
PICO Info
in preparation
Languages

English

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