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Pseudoboehmite as a drug delivery system for acyclovir.

Author: BernussiAyrton, MunhozAntonio Hortencio, PeresRenato Meneghetti, RossiMaura Vincenza, SarmentoBruno, SousaJéssica Maiara Leme, WarzywodaJuliusz, de LimaNelson Batista, de OliveiraMariana Oliva, de OliveiraRene Ramos

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the potential of pseudoboehmite nanoparticles to improve the oral bioavailability of acyclovir. The researchers synthesized high purity pseudoboehmite nanoparticles and confirmed their presence using various techniques. In vivo tests in Wistar rats showed that the administration of acyclovir with pseudoboehmite increased drug content in plasma by 4.6 times. The study concludes that pseudoboehmite nanoparticles are a promising drug delivery system for acyclovir with low toxicity.
Paper Details　
Original Abstract of the Article :
Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the o...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322319/

データ提供：米国国立医学図書館（NLM）

Pseudoboehmite Nanoparticles for Acyclovir Delivery

Herpes simplex virus, like a persistent desert wind, can cause recurrent infections. Acyclovir, a medication commonly used to treat herpes infections, has limited oral bioavailability due to its low permeability across the gastrointestinal membrane. This research explores the use of pseudoboehmite nanoparticles as a drug delivery system to enhance the bioavailability of acyclovir.

Improving Acyclovir Delivery

The researchers synthesized high purity pseudoboehmite nanoparticles using the sol-gel method and evaluated their ability to enhance the delivery of acyclovir. This is like finding a new way to transport water across the desert, ensuring its delivery to thirsty travelers. In vitro studies demonstrated that the addition of pseudoboehmite nanoparticles significantly increased the release of acyclovir, suggesting its potential to improve drug bioavailability and efficacy. In vivo tests in rats confirmed that the administration of acyclovir with pseudoboehmite nanoparticles resulted in significantly higher plasma drug concentrations compared to acyclovir alone.

Potential for New Treatment Approaches

This research offers a promising approach to enhance the delivery and efficacy of acyclovir, a medication widely used to treat herpes infections. This is like discovering a new oasis in the desert, offering a valuable resource for those in need. The use of pseudoboehmite nanoparticles as a drug delivery system holds potential for improving treatment outcomes for patients with herpes infections.

Dr.Camel's Conclusion

This research explores a novel approach to enhance the delivery of acyclovir, a medication crucial for managing herpes infections. The use of pseudoboehmite nanoparticles as a drug delivery system holds significant promise for improving drug bioavailability and efficacy. This innovation, like a clever camel finding a new water source, offers hope for more effective treatment strategies for patients with herpes infections.

Date :
  1. Date Completed 2021-11-08
  2. Date Revised 2021-11-08
Further Info :

Pubmed ID

34326377

DOI: Digital Object Identifier

PMC8322319

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PICO Info
in preparation
Languages

English

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