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[Importance of HLA in Determining Individual Differences in the Onset of Adverse Drug Reactions].

Author: AokiShigeki

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Idiosyncratic drug toxicity (IDT) is strongly associated with specific human leukocyte antigen (HLA) polymorphisms. This review describes a transgenic mouse model (HLA-Tg) developed to study IDT. The model was used to investigate the mechanism of abacavir-induced liver injury, which is HLA-dependent. The HLA-Tg model offers a valuable tool for understanding and predicting drug hypersensitivity.
Paper Details　
Original Abstract of the Article :
Individuals vary in their susceptibility to adverse reactions to medications, some of which can be potentially life-threatening. Idiosyncratic drug toxicity (IDT) has been shown to be strongly associated to specific polymorphisms in genes encoding human leukocyte antigens (HLAs) by recent genome-wid...See full text at original site
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引用元：
https://doi.org/10.1248/yakushi.21-00120

データ提供：米国国立医学図書館（NLM）

The Hidden Role of HLA in Drug Reactions

Imagine a desert landscape where some plants are harmless, while others are poisonous. That's how our bodies can react to different medications. Some individuals experience no problems, while others have severe reactions. This study focuses on a specific type of drug reaction, known as idiosyncratic drug toxicity (IDT), and the role of human leukocyte antigens (HLAs) in these reactions.

The researchers are exploring the link between specific HLA genes and IDT. They're looking at how genetic variations in HLA genes can influence an individual's susceptibility to drug reactions. They are also investigating the underlying mechanisms that cause these reactions.

The study found that specific HLA variations can significantly influence an individual's risk of developing IDT. They discovered a clear link between HLA-B*57:01 and abacavir, a drug used to treat HIV. This research helps explain why some individuals have severe reactions to certain drugs, and it could lead to personalized medicine approaches to prevent these reactions.

Unlocking the Secrets of Drug Reactions

This study provides a valuable glimpse into the complex interplay between genetics and drug reactions. It sheds light on the crucial role of HLA genes in determining an individual's susceptibility to IDT. This knowledge can help us develop more effective ways to identify and manage drug reactions.

Understanding Your Unique Landscape

It's important to talk to your doctor about any family history of drug reactions and to be open about your own experiences with medications. This study emphasizes the importance of personalized medicine, where understanding our unique genetic landscape can help us make safer and more effective treatment choices.

Dr. Camel's Conclusion

The desert of medicine is vast and varied. This research highlights the importance of understanding our own genetic makeup to navigate this landscape safely. Remember, being informed and talking to your doctor can help us make the best decisions for our health.

Date :
  1. Date Completed 2021-12-27
  2. Date Revised 2021-12-27
Further Info :

Pubmed ID

34334545

DOI: Digital Object Identifier

10.1248/yakushi.21-00120

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Languages

Japanese

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