Paper Details
- Home
- Paper Details
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma.
Author: ChenXiao-Yan, GaoAn-Hui, GaoZhi-Wei, HanXiao-Feng, HouJian, HuXiao-Bei, HuangHong-Hui, LiJia, NanFa-Jun, ShenLi-Jing, ShengLi, SuMing-Bo, WeiXiao-Li, YuSong-da, ZhangYang-Ming, ZhangYi-Fan, ZhangYue, ZhouYu-Bo
Original Abstract of the Article :
HDAC inhibitors (HDACis) have been intensively studied for their roles and potential as drug targets in T-cell lymphomas and other hematologic malignancies. Bisthianostat is a novel bisthiazole-based pan-HDACi evolved from natural HDACi largazole. Here, we report the preclinical study of bisthianost...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976035/
データ提供:米国国立医学図書館(NLM)
Bisthianostat: A New Oasis in the Desert of Multiple Myeloma Treatment
Multiple myeloma, a type of blood cancer, can be a formidable adversary. This study, like a brave explorer venturing into the desert of myeloma research, investigates a new therapeutic agent called bisthianostat, a histone deacetylase inhibitor (HDACi), for the treatment of relapsed or refractory multiple myeloma (R/R MM).
A Promising New Weapon: Bisthianostat Shows Potential in Preclinical and Early Human Studies
The study, like a caravan discovering a new source of water in the desert, found that bisthianostat exhibited significant antitumor activity both in preclinical models and in early human trials. This promising finding suggests that bisthianostat might offer a new therapeutic option for patients with R/R MM, particularly when used in combination with existing therapies.
A Journey of Hope: Navigating the Desert of R/R MM Treatment
This research offers a glimmer of hope in the desert of R/R MM treatment, highlighting the potential of bisthianostat as a novel therapeutic agent. It encourages continued research into this promising compound, aiming to refine its therapeutic potential and improve outcomes for patients with R/R MM.
Dr. Camel's Conclusion
This study introduces bisthianostat as a potential new oasis in the desert of R/R MM treatment. Its promising preclinical and early human data suggest that bisthianostat might offer a new therapeutic option for patients struggling with this challenging condition. This research encourages continued exploration and development of bisthianostat as a potential weapon in the fight against multiple myeloma. The desert of cancer research is vast and challenging, but with continuous exploration and innovation, new oases of hope are constantly emerging.
Date :
- Date Completed 2022-04-05
- Date Revised 2022-10-27
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.