Alkylating Agents, the Road Less Traversed, Changing Anticancer Therapy.

Author: KaratiDipanjan, KumarDileep, MahadikKakasaheb Ramoo, TrivediPiyush

Paper Details 
Original Abstract of the Article :
Cancer is considered one of the gruelling challenges and poses a grave health hazard across the globe. According to the International Agency for Research on Cancer (IARC), new cancer cases increased to 18.1 million in 2018, with 9.6 million deaths, bringing the global cancer rate to 23.6 million by ...See full text at original site
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引用元:
https://doi.org/10.2174/1871520621666210811105344

データ提供:米国国立医学図書館(NLM)

Alkylating Agents: A Journey of Innovation in Cancer Therapy

Cancer remains a formidable challenge, demanding relentless innovation in treatment approaches. This study explores the evolution of alkylating agents, a class of anticancer drugs, since their discovery in 1942. The study highlights the significant impact of nitrogen mustard, the first alkylating agent, on cancer chemotherapy. The authors discuss the challenges of alkylating agent toxicity and the ongoing efforts to improve their efficacy and target specificity. This review focuses on the versatility of alkylating agents and the Structure Activity Relationship (SAR) of different classes of these compounds. The study aims to provide a deeper understanding of alkylating agents, paving the way for the development of new drugs with enhanced efficacy and reduced side effects.

Alkylating Agents: A Powerful Tool in the Fight Against Cancer

Alkylating agents remain a vital component of cancer chemotherapy, despite their associated toxicities. The authors highlight the ongoing efforts to enhance the efficacy and target specificity of alkylating agents, minimizing side effects while maximizing therapeutic benefits. This research underscores the importance of continued research and development to optimize existing therapies and discover new, more effective cancer treatments.

The Future of Cancer Treatment: A Collaborative Approach

The fight against cancer requires a collaborative approach involving researchers, clinicians, and patients. This study emphasizes the importance of ongoing research to develop new and improved treatments, including the development of new alkylating agents with enhanced target specificity and reduced toxicity. It is important to remember that cancer treatment is a multifaceted journey, and patients should be actively involved in their care and treatment decisions.

Dr.Camel's Conclusion

The ongoing journey to combat cancer is a fascinating story of innovation and perseverance. This study highlights the evolution of alkylating agents, a testament to the tireless efforts of researchers to find better treatments for this complex disease. The future of cancer treatment will likely involve a combination of traditional and novel therapies, including the ongoing refinement of alkylating agents, to provide patients with the best possible care.

Date :
  1. Date Completed 2022-05-17
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

34382529

DOI: Digital Object Identifier

10.2174/1871520621666210811105344

Related Literature

SNS
PICO Info
in preparation
Languages

English

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