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[Oral chemotherapy (sonigegib) of extensive basal cell carcinoma, about 4 cases].

Author: Angioi-DuprezK, ColnéJ, GranelleF, MaaloufT

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Oral chemotherapy with sonidegib was effective in treating advanced, non-metastatic basal cell carcinoma (BCC) in four patients where surgery was contraindicated. One patient achieved complete tumor regression, while three experienced partial regression. The treatment was associated with side effects including nausea, muscle cramping, dysgeusia, and weight loss.
Paper Details　
Original Abstract of the Article :
Basal cell carcinoma (BCC) is the most frequent cutaneous carcinoma. Its incidence is constantly increasing, primarily due to sun exposure during the two first decades of life. The lower lid and medial canthus are the most common locations. In the majority of cases, surgery with sufficient margins i...See full text at original site
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引用元：
https://doi.org/10.1016/j.jfo.2021.04.003

データ提供：米国国立医学図書館（NLM）

Oral Chemotherapy for Advanced Basal Cell Carcinoma: A Case Series

Basal cell carcinoma (BCC), the most common type of skin cancer, is a challenging condition to treat, especially in advanced cases. This case series is like a beacon of hope, presenting the results of oral chemotherapy (sonigegib) in four patients with advanced, inoperable BCC. The authors report favorable outcomes in the majority of cases, with significant regression of the tumors. They also highlight the importance of careful monitoring for potential side effects and the need for a multidisciplinary approach to treatment.

Oral Chemotherapy Offers a Potential Solution for Inoperable BCC

This case series demonstrates the potential of oral chemotherapy (sonigegib) as a viable treatment option for patients with advanced basal cell carcinoma. The authors highlight the effectiveness of this approach, especially when surgery is not feasible. This is like discovering a new source of water in a dry and barren desert, offering a glimmer of hope for patients with limited treatment options.

Living with Advanced BCC: A Collaborative Approach

This research underscores the importance of a multidisciplinary approach to treating advanced basal cell carcinoma. The authors emphasize the need for careful monitoring and management of potential side effects, requiring close collaboration between oncologists, dermatologists, and other healthcare professionals. This is like a well-organized camel caravan, where each member plays a crucial role in ensuring the success of the journey.

Dr.Camel's Conclusion

This case series demonstrates the effectiveness of oral chemotherapy (sonigegib) in the treatment of advanced, inoperable basal cell carcinoma. The authors highlight the importance of careful monitoring for side effects and the need for a multidisciplinary approach to treatment. This research is like a caravan navigating a challenging desert, offering hope and potential solutions for individuals facing the challenges of advanced BCC.
Date :
  1. Date Completed 2021-09-29
  2. Date Revised 2021-09-29
Further Info :

Pubmed ID

34417062

DOI: Digital Object Identifier

10.1016/j.jfo.2021.04.003

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Article Analysis
・Side Effects of sonidegib
SNS
PICO Info
in preparation
Languages

French

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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