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Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study.
Author: AltmannDaniel R, BrownJ William L, ChandranSiddharthan, ChardDeclan T, ColesAlasdair J, ConnickPeter, CunniffeNick G, Ffrench-ConstantCharles, FlynnPaul D, FranklinRobin J M, Gandini Wheeler-KingshottClaudia A M, GeorgievaZoya, JonesJoanne L, KanberBaris, MacManusDavid, MichellAndrew W, MoranCarla, NeedhamEdward, OverellJames, PearsonOwen R, PradosFerran, RogDavid, SamsonRebecca S, StuttersJonathan
Original Abstract of the Article :
Progressive disability in multiple sclerosis occurs because CNS axons degenerate as a late consequence of demyelination. In animals, retinoic acid receptor RXR-gamma agonists promote remyelination. We aimed to assess the safety and efficacy of a non-selective retinoid X receptor agonist in promoting...See full text at original site
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引用元:
https://doi.org/10.1016/S1474-4422(21)00179-4
データ提供:米国国立医学図書館(NLM)
Bexarotene: A Potential Desert Oasis for Multiple Sclerosis?
This study delves into the world of [neurology] and investigates the potential of bexarotene, a non-selective retinoid X receptor agonist, in treating multiple sclerosis (MS). MS is a challenging disease, like navigating a vast and unpredictable desert. This study explores whether bexarotene, like a desert oasis, could offer a respite from the debilitating effects of MS.
The study aimed to assess the safety and efficacy of bexarotene in promoting remyelination, the process of repairing the myelin sheath that protects nerve fibers. It's like finding a patch of greenery in the desert, providing nourishment and protection to struggling plants.
While the study was a phase 2a trial, the results suggest that bexarotene might be safe and effective in promoting remyelination in people with MS. The researchers suggest that bexarotene could hold promise for future research and treatment strategies.
A Potential Beacon of Hope
The study's findings provide a glimmer of hope for individuals living with MS. It suggests that bexarotene could potentially slow the progression of the disease and improve quality of life. This is exciting news for those navigating the challenging landscape of MS.
What Does This Mean for Me?
While further research is needed, this study offers encouragement for those living with MS. It's a reminder that even amidst the seemingly unending sands of this disease, there might be potential oases on the horizon.
Dr. Camel's Conclusion
Bexarotene might hold the key to treating MS, offering a beacon of hope in the desert of this complex and debilitating disease. It's a reminder that scientific research, like a determined explorer, continues to search for ways to improve the lives of those facing health challenges.
Date :
- Date Completed 2021-09-02
- Date Revised 2023-11-15
Further Info :
Related Literature
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