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Valproate activates the Snf1 kinase in Saccharomyces cerevisiae by decreasing the cytosolic pH.

Author: AzizKerestin, GreenbergMiriam L, HüttemannMaik, KanePatricia M, LazcanoPablo, ReynoldsChristian A, SalsaaMichael, SchmidtkeMichael W, TarsioMaureen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Valproate (VPA), a widely used mood stabilizer, was found to lower cytosolic pH in yeast cells, leading to decreased glycolytic flux and activation of Snf1 kinase, resulting in increased expression of normally repressed metabolic genes. These findings suggest a central role for cytosolic pH in regulating the metabolic program of yeast cells.
Paper Details　
Original Abstract of the Article :
Valproate (VPA) is a widely used mood stabilizer, but its therapeutic mechanism of action is not understood. This knowledge gap hinders the development of more effective drugs with fewer side effects. Using the yeast model to elucidate the effects of VPA on cellular metabolism, we determined that th...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449051/

データ提供：米国国立医学図書館（NLM）

Valproate: A Mood Stabilizer's Desert Journey

The field of [pharmacology] is constantly seeking to understand the mechanisms of action of various medications. This research investigates the effects of [valproate (VPA)], a widely used [mood stabilizer], on cellular metabolism in [Saccharomyces cerevisiae], a model organism. The study utilizes a [yeast model] to explore the effects of [VPA] on gene expression, [Snf1 kinase] activation, and cellular pH. The researchers discovered that [VPA] activated [Snf1 kinase] by decreasing the [cytosolic pH], leading to changes in gene expression and metabolic pathways.

Valproate: A Desert Wind Shaping Metabolism

The study reveals the intricate link between [valproate] and cellular metabolism, specifically the role of [cytosolic pH] in regulating [Snf1 kinase] activation and gene expression. It's like a desert wind shaping the sand dunes – [valproate] influences the cellular landscape, affecting various metabolic processes.

Understanding Valproate's Actions: A Camel's Perspective

This research provides valuable insights into the mechanisms underlying the therapeutic effects of [valproate]. It highlights the importance of considering the impact of medications on cellular metabolism. Remember, just as a camel adapts to the desert's fluctuating conditions, we must understand how medications interact with our bodies at the cellular level.

Dr. Camel's Conclusion

This study delves into the fascinating world of cellular metabolism and its influence on the effectiveness of medications. It emphasizes the need for continued research to understand the complex interactions between medications and the human body. Remember, just as a camel learns to navigate the vast desert, we must continue to explore the intricacies of our bodies to find the best treatments for our health.

Date :
  1. Date Completed 2021-11-24
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

34428448

DOI: Digital Object Identifier

PMC8449051

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Languages

English

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