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Comparison of antihypertensive effect and pharmacokinetics of conventional and extended release felodipine tablets in patients with arterial hypertension.

Author: DahlöfC, ElmfeldtD, HednerT, SjögrenE

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Felodipine, an antihypertensive drug, was effective in lowering blood pressure in patients with moderate to severe hypertension. The extended-release formulation provided a more even plasma concentration curve and was effective for 24 hours after a single dose.
Paper Details　
Original Abstract of the Article :
In 2 separate double-blind, placebo-controlled, crossover studies, the antihypertensive effect and felodipine plasma concentrations were studied after 2 different formulations of felodipine. Both trials studied patients who had previously responded unsatisfactorily to conventional triple therapy (be...See full text at original site
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引用元：
https://doi.org/10.2165/00003495-198700343-00027

データ提供：米国国立医学図書館（NLM）

Felodipine: A Camel's Guide to Blood Pressure Control

High blood pressure is like a relentless desert wind, constantly pushing against the body's delicate systems. This study explores the effects of felodipine, a medication used to tame this wind. The researchers investigated two different formulations of felodipine – a conventional tablet taken twice daily and an extended-release tablet taken once daily.

Two Felodipine Formulations: A Tale of Two Tablets

Both formulations effectively reduced blood pressure. The conventional tablet provided relief for 12 hours, but the extended-release tablet offered a more consistent 24-hour blood pressure control. This is like comparing two types of camels – one needs frequent breaks for water, while the other can journey longer distances with its stored reserves. This study suggests that the extended-release formulation might be more convenient for patients, like a camel that can travel further on a single oasis.

Finding a Balance: Blood Pressure and Side Effects

The researchers were careful to ensure that neither formulation caused any significant side effects. It’s like navigating a desert with a gentle breeze – effective in keeping the sand down but not so strong as to cause discomfort.

Dr.Camel's Conclusion

This study shows that felodipine can be an effective camel in the fight against high blood pressure. The extended-release formulation offers a more convenient and sustained approach, potentially providing a smoother and more comfortable journey through the desert of hypertension.

Date :
  1. Date Completed 1988-05-02
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

3443058

DOI: Digital Object Identifier

10.2165/00003495-198700343-00027

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・Side Effects of felodipine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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