Weak antibody response to three doses of mRNA vaccine in kidney transplant recipients treated with belatacept.

Author: AmroucheLucile, AnglicheauDany, BererhiLynda, BurgerCarole, ChavarotNathalie, DivardGillian, LanternierFanny, LegendreChristophe, Leruez-VilleMarianne, MartinezFrank, MorelAntoine, Sberro-SoussanRebecca, ScemlaAnne, SerrisAlexandra, VilainEstelle, ZuberJulien

Paper Details 
Original Abstract of the Article :
Poor responses to mRNA COVID-19 vaccine have been reported after 2 vaccine injections in kidney transplant recipients (KTRs) treated with belatacept. We analyzed the humoral response in belatacept-treated KTRs without a history of SARS-CoV-2 infection who received three injections of BNT162b2-mRNA C...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906354/

データ提供:米国国立医学図書館(NLM)

mRNA Vaccine Response in Belatacept-Treated Kidney Transplant Recipients: A Desert Oasis of Research

Kidney transplant recipients (KTRs) often face challenges in mounting an adequate immune response to vaccines. This study explores the humoral response to three doses of BNT162b2-mRNA COVID-19 vaccine in belatacept-treated KTRs, a group known for their compromised immune systems. Researchers meticulously analyzed data from a cohort of belatacept-treated KTRs, observing a weak antibody response to the vaccine in those without a history of COVID-19 infection. In contrast, those with prior COVID-19 infection exhibited a strong antibody response. The study highlights the need for alternative strategies to improve vaccine immunogenicity in belatacept-treated KTRs and emphasizes the importance of continued research to better understand vaccine response in this vulnerable population.

mRNA Vaccine Response: A Desert Oasis of Insights in Transplant Immunology

This study sheds light on the complex interplay of immunosuppressive medications, prior infection, and vaccine response in kidney transplant recipients. The research, like a caravan of explorers navigating the vast desert of transplant immunology, provides valuable insights into the challenges associated with vaccination in this vulnerable population. The findings underscore the need for personalized strategies to improve vaccine efficacy and protect KTRs from infectious diseases.

Navigating the Desert of Transplant Immunology: A Path to Protection

This study emphasizes the importance of ongoing research to develop personalized strategies for improving vaccine efficacy in kidney transplant recipients. The research highlights the need for a multidisciplinary approach, involving nephrologists, immunologists, and infectious disease specialists, to ensure the best possible care for KTRs. This study provides a roadmap for a more effective and tailored approach to vaccine management in this vulnerable population.

Dr.Camel's Conclusion

This study, like a desert oasis offering a refuge in a challenging landscape, provides valuable insights into the complex interplay of immunosuppressive medications, prior infection, and vaccine response in kidney transplant recipients. The findings underscore the need for continued research to develop personalized strategies to improve vaccine efficacy and protect this vulnerable population.

Date :
  1. Date Completed 2021-12-03
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

34431207

DOI: Digital Object Identifier

PMC9906354

Related Literature

SNS
PICO Info
in preparation
Languages

English

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