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Early weight loss is an independent risk factor for shorter survival and increased side effects in patients with metastatic colorectal cancer undergoing first-line treatment within the randomized Phase III trial FIRE-3 (AIO KRK-0306).

Author: AlgülHana, DeckerThomas, EricksonNicole Tonya, GesenhuesAlena Britta, HeinemannVolker, HeintgesTobias, HolchJulian W, HöffkesHeinz-Gert, KahlChristoph, KaiserFlorian, KianiAlexander, KullmannFrank, LerchMarkus M, LinkHartmut, LiuLian, MichlMarlies, ModestDominik P, MoehlerMarkus, RicardIngrid, ScheithauerWerner, StintzingSebastian, TheurichSebastian, von WeikersthalLudwig Fischer

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study found that early weight loss (EWL) in patients with metastatic colorectal cancer (mCRC) was associated with worse overall survival and progression-free survival. EWL was also associated with a higher incidence of side effects, such as diarrhea, edema, fatigue, nausea, and vomiting. The study also found that EWL was significantly associated with patient age, with older patients being at higher risk of EWL. These findings suggest that early preventative measures targeted at weight maintenance should be evaluated, especially in elderly patients being at highest risk of EWL.
Paper Details　
Original Abstract of the Article :
Body weight loss is frequently regarded as negatively related to outcomes in patients with malignancies. This retrospective analysis of the FIRE-3 study evaluated the evolution of body weight in patients with metastatic colorectal cancer (mCRC). FIRE-3 evaluated first-line FOLFIRI (folinic acid, flu...See full text at original site
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引用元：
https://doi.org/10.1002/ijc.33775

データ提供：米国国立医学図書館（NLM）

Early Weight Loss: A Prognostic Factor for Metastatic Colorectal Cancer

Metastatic colorectal cancer (mCRC) is a serious disease, and understanding prognostic factors is crucial for guiding treatment decisions. This retrospective analysis of the FIRE-3 study investigated the impact of early weight loss (EWL) on patient outcomes in mCRC patients undergoing first-line treatment. The researchers found that EWL was significantly associated with a shorter overall survival and progression-free survival. Furthermore, EWL was linked to a higher frequency of adverse events. This research highlights the importance of early interventions targeted at weight maintenance, particularly in elderly patients who may be at higher risk of EWL.

Early Weight Loss and Survival in mCRC: A Critical Link

This study sheds light on the significant association between early weight loss (EWL) and poorer outcomes in patients with metastatic colorectal cancer (mCRC). The researchers found that EWL was independently associated with a shorter overall survival and progression-free survival. These findings underscore the importance of addressing weight loss in mCRC patients, particularly during the early stages of treatment.

Weight Management: A Vital Component in Cancer Care

This study highlights the crucial role of weight management in cancer care, especially in patients with metastatic colorectal cancer (mCRC). The findings indicate that early weight loss is a significant prognostic factor, impacting survival and the frequency of adverse events. This underscores the need for early interventions aimed at maintaining weight, particularly for elderly patients who may be at higher risk of EWL.

Dr.Camel's Conclusion

Like navigating a challenging desert journey, patients with metastatic colorectal cancer (mCRC) often face a difficult path to recovery. This research provides valuable insights into the impact of early weight loss (EWL), demonstrating its association with poorer outcomes. It emphasizes the importance of weight maintenance strategies in cancer care, offering hope for improved survival and reduced adverse effects.
Date :
  1. Date Completed 2021-12-20
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

34431518

DOI: Digital Object Identifier

10.1002/ijc.33775

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