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The Treatment of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Systematic Review with a Pooled Analysis of Only Surgery versus Combined Protocols.

Author: BedogniAlberto, CampisiGiuseppina, CanepaFederica, Del GaizoCarmine, Di FedeOlga, FuscoVittorio, GalvanoAntonio, MauceriRodolfo, PanzarellaVera, PizzoGiuseppe, TozzoPietro

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review and pooled analysis investigated the efficacy of surgical techniques for medication-related osteonecrosis of the jaw (MRONJ). Combined conservative surgery with non-invasive procedures showed a significant improvement rate at 6 months compared to aggressive surgery alone. While total resolution rates were similar, conservative surgery combined with adjuvants like ozone, LLLT, or blood components achieved partial or full healing in all stages. More research is needed to confirm these findings.
Paper Details　
Original Abstract of the Article :
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction of antiresorptive and antiangiogenic agents, and it is also a potentially painful and debilitating condition. To date, no specific studies have prospectively evaluated the efficacy of its treatment and no robust standa...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392050/

データ提供：米国国立医学図書館（NLM）

Medication-Related Osteonecrosis of the Jaw: A Comprehensive Review

This research delves into the complexities of medication-related osteonecrosis of the jaw (MRONJ), a serious adverse reaction associated with certain medications. The authors conducted a systematic review, analyzing various treatment approaches and their effectiveness in managing this debilitating condition.

Navigating MRONJ Treatment: A Review of Surgical Techniques

This review explores the effectiveness of different surgical techniques in managing MRONJ. The authors found that combining conservative surgery with non-invasive procedures like ozone, LLLT, or blood component + Nd:YAG may be a promising approach, achieving partial or full healing in all stages of MRONJ. This research underscores the importance of individualized treatment strategies based on the specific needs of each patient.

Finding Solutions for a Challenging Condition

This research sheds light on the potential of multi-modal approaches in managing MRONJ. Just as a camel adapts to its harsh desert environment, doctors must be adept at finding solutions that address the unique challenges of this condition.

Dr. Camel's Conclusion

MRONJ is like a desert storm, unpredictable and potentially devastating. However, this review offers a valuable roadmap for navigating this challenging condition. By combining surgical expertise and innovative non-invasive therapies, we can create oases of healing and hope for patients battling MRONJ.

Date :
  1. Date Completed 2021-09-03
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

34444181

DOI: Digital Object Identifier

PMC8392050

Related Literature

Article Analysis
・Effective treatment of osteonecrosis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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