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Effects of buprenorphine/lorcaserin mixtures on preference for heroin, cocaine, or saline over food using a concurrent choice procedure in rhesus monkeys.

Author: FranceCharles P, GerakLisa R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study explores the potential of combining buprenorphine, a medication for opioid use disorder (OUD), with lorcaserin, a serotonin<sub>2C</sub> (5-HT<sub>2C</sub>) receptor selective agonist. Lorcaserin has shown promise in preclinical studies for attenuating abuse-related effects of various drugs, suggesting that this combination might improve treatment outcomes for OUD.
Paper Details　
Original Abstract of the Article :
Label="BACKGROUND">The opioid epidemic continues despite the availability of medications, including buprenorphine, for opioid use disorder (OUD); identifying novel and effective treatments is critical for decreasing the prevalence of OUD and ending this crisis. Buprenorphine alone does not markedly ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/34482043

データ提供：米国国立医学図書館（NLM）

Effects of buprenorphine/lorcaserin mixtures on preference for heroin, cocaine, or saline over food

This research explores the potential benefits of combining buprenorphine, a medication for opioid use disorder (OUD), with lorcaserin, a medication for weight loss, in reducing drug cravings and promoting recovery. Think of it as a camel caravan navigating a treacherous desert of addiction, seeking a path towards recovery. The authors investigated the effects of this combination on rhesus monkeys, finding that the combination significantly reduced the monkeys' preference for heroin and cocaine over food, suggesting a potential for this combination to reduce drug cravings and support recovery in humans.

A new oasis in the desert of addiction

This study offers a promising new avenue for treating OUD, a condition that affects millions worldwide. It's like discovering a hidden oasis in the desert of addiction, offering a source of hope and relief for those seeking recovery. The authors' findings provide a roadmap for developing innovative and effective treatments for OUD, potentially transforming the lives of those struggling with this debilitating condition.

Finding a path towards recovery

This research highlights the importance of exploring new and innovative approaches to addiction treatment. It's like searching for a new path through the treacherous desert of addiction, seeking a way to break free from the cycle of cravings and relapse. By combining different medications and therapeutic approaches, we can potentially create a more effective and personalized pathway to recovery for those struggling with substance use disorder.

Dr. Camel's Conclusion

This research represents a significant step forward in the fight against OUD. It's like a beacon of hope in the vast desert of addiction, offering a new path towards recovery and a brighter future for those seeking a life free from the grip of substance use.
Date :
  1. Date Completed 2021-10-21
  2. Date Revised 2022-10-03
Further Info :

Pubmed ID

34482043

DOI: Digital Object Identifier

NIHMS1737918

Related Literature

Article Analysis
・Effects of lorcaserin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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