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Fampridine and Acetazolamide in EA2 and Related Familial EA: A Prospective Randomized Placebo-Controlled Trial.

Author: FrankeChristiana, MansmannUlrich, MuthCarolin, SchölsLudger, StruppMichael, SynofzikMatthis, TeufelJulian, TimmannDagmar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This phase III, randomized, double-blind, placebo-controlled, 3-period crossover trial evaluated the efficacy and safety of fampridine and acetazolamide for episodic ataxia type 2 (EA2). Both drugs significantly reduced the number of attacks compared to placebo. Fampridine had fewer side effects than acetazolamide. These findings suggest that both drugs are effective treatments for EA2.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To determine the efficacy and safety of the treatment with prolonged-release 4-aminopyridine (fampridine) and acetazolamide for patients with episodic ataxia type 2 (EA2), patients with EA2 were treated with a random sequence of fampridine, acetazolamide, and placebo in a 3-period crossov...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382428/

データ提供：米国国立医学図書館（NLM）

The Efficacy of Fampridine and Acetazolamide in Episodic Ataxia Type 2: A Journey Through the Desert of Neurological Disorders

This research, like a camel caravan traversing a vast and complex desert, explores the efficacy of fampridine and acetazolamide in treating episodic ataxia type 2 (EA2), a neurological disorder characterized by episodes of sudden loss of coordination and balance. The researchers, like skilled explorers seeking a hidden oasis of solutions, are meticulously evaluating the effectiveness of these medications in managing EA2 symptoms. The study, like a well-mapped oasis, reveals that both fampridine and acetazolamide significantly reduce the number of attacks in patients with EA2, offering a potential path toward improved quality of life for individuals struggling with this debilitating condition.

A New Oasis in the Desert of Neurological Disorders: Effective Treatments for EA2

This study, like a beacon of hope in the vast and often challenging desert of neurological disorders, demonstrates the efficacy of fampridine and acetazolamide in treating episodic ataxia type 2. The researchers' findings, like a well-mapped oasis, reveal that these medications significantly reduce the number of attacks, offering a potential path toward improved quality of life for individuals with EA2.

Navigating the Desert of Neurological Disorders: A Journey Towards Relief

This study, like a camel caravan seeking a smoother path through a treacherous desert, explores the efficacy of fampridine and acetazolamide in managing episodic ataxia type 2. The researchers' findings, like a well-mapped oasis, reveal that these medications significantly reduce the number of attacks, offering a potential path towards improved quality of life for individuals with EA2.

Dr. Camel's Conclusion

This study, like a camel caravan traversing a vast and complex desert, explores the efficacy of fampridine and acetazolamide in treating episodic ataxia type 2. The researchers' findings, like a well-mapped oasis, reveal that both medications significantly reduce the number of attacks, offering a potential path toward improved quality of life for individuals struggling with this debilitating condition.
Date :
  1. Date Completed n.d.
  2. Date Revised 2022-08-02
Further Info :

Pubmed ID

34484942

DOI: Digital Object Identifier

PMC8382428

Related Literature

Article Analysis
・Side Effects of acetazolamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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