Lung cancer treated abroad with receptor tyrosine kinase inhibitor.

Author: BrustugunOdd Terje, EideInger Johanne Zwicky

Paper Details 
Original Abstract of the Article :
BACKGROUND: Activating RET fusions are oncogenic drivers in multiple cancers and are identified in 1-2 % of non-small cell lung cancers (NSCLC). Selpercatinib and pralsetinib are tyrosine kinase inhibitors selectively targeting RET and with clinical activity in RET-positive NSCLC. CASE PRESENTATION...See full text at original site
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引用元:
https://doi.org/10.4045/tidsskr.21.0147

データ提供:米国国立医学図書館(NLM)

Targeted Therapy for RET Fusion-Positive Lung Cancer

This case presentation delves into the exciting field of [precision medicine] by showcasing the successful treatment of [advanced lung adenocarcinoma] with a [tyrosine kinase inhibitor] targeting a specific genetic mutation. The patient presented with a [KIF5B-RET fusion], a rare genetic alteration that drives tumor growth. The use of [pralsetinib] through a [compassionate use program] resulted in [relief of symptoms] and [radiological partial response], demonstrating the effectiveness of targeted therapy in this context.

Precision Medicine: A Powerful Tool in the Fight Against Cancer

This case highlights the power of precision medicine in identifying and treating cancer based on individual genetic characteristics. The patient's response to pralsetinib, specifically targeting the KIF5B-RET fusion, showcases the potential of targeted therapies to deliver personalized and effective treatment.

The Shifting Sands of Cancer Treatment

The use of next-generation sequencing (NGS) to identify specific genetic mutations in cancer is a game-changer. It's like having a map to navigate the complex terrain of cancer treatment. By pinpointing the unique genetic drivers of each tumor, we can tailor treatment strategies for optimal outcomes. This approach represents a significant shift in the landscape of cancer care, offering hope and personalized solutions for patients.

Dr.Camel's Conclusion

This case study underscores the transformative power of precision medicine in cancer treatment. The identification and targeting of specific genetic alterations like KIF5B-RET fusion using NGS opens up new avenues for personalized therapy. It's akin to navigating the desert with a compass, leading us to a more effective and targeted path to conquer this formidable foe.

Date :
  1. Date Completed 2021-10-18
  2. Date Revised 2021-11-19
Further Info :

Pubmed ID

34505490

DOI: Digital Object Identifier

10.4045/tidsskr.21.0147

Related Literature

SNS
PICO Info
in preparation
Languages

Norwegian

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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