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Effects of Tyrosine Kinase Inhibitors on Blood Pressure in Patients with Unresectable or Advanced Recurrent Renal Cell Carcinoma-Bayes-Mixed Treatment Comparison Meta-Analysis.

Author: InoueTadao, IseYuya, MurayamaRumi, SatohEisaku, YamaguchiShion

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

This study clinically evaluated five tyrosine kinase inhibitors (TKIs) used to treat renal cell carcinoma in Japan using Bayes-mixed treatment comparison meta-analysis. The study aimed to develop a decision-making model for selecting the optimal TKI based on its effects on blood pressure and response rate.
Paper Details　
Original Abstract of the Article :
Although cytokine therapy has been a common drug therapy for renal cell carcinoma for long since the 1980s, the evidence for the rationale of this therapy has been limited. Currently, 7 molecular targeted drugs(ie, sorafenib, sunitinib, axitinib, pazopanib, cabozantinib, everolimus, and temsirolimus...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/34521793

データ提供：米国国立医学図書館（NLM）

Tyrosine Kinase Inhibitors: Navigating the Complexities of Renal Cell Carcinoma Treatment

Renal cell carcinoma, a type of kidney cancer, often requires complex and individualized treatments. This study focused on the effects of tyrosine kinase inhibitors (TKIs), a class of drugs that target specific proteins involved in cell growth and division, on blood pressure in patients with renal cell carcinoma. Using a meta-analysis of clinical trials, the researchers aimed to compare the effects of various TKIs on blood pressure and their effectiveness in treating renal cell carcinoma.

Understanding the Impact of TKIs on Blood Pressure

The study found that TKIs, particularly cabozantinib and axitinib, were more likely to affect blood pressure compared to other TKIs, such as sunitinib and sorafenib. The findings highlight the importance of monitoring blood pressure closely in patients receiving TKIs for renal cell carcinoma. The study also confirmed the significant prevalence of hypertension in patients treated with certain TKIs, underscoring the need for careful patient selection and management.

The Importance of Personalized Treatment Strategies

This research emphasizes the importance of personalized treatment strategies for renal cell carcinoma. The study shows that different TKIs have different effects on blood pressure and effectiveness in treating the disease. Therefore, it is crucial for healthcare providers to consider individual patient factors, such as pre-existing conditions and drug interactions, when selecting the most appropriate TKI treatment.

Dr. Camel's Conclusion

Navigating the treatment landscape for renal cell carcinoma can be like traversing a vast desert. Each TKI is like a unique oasis, offering different benefits and challenges. This research provides valuable insights into the impact of TKIs on blood pressure, helping healthcare providers choose the right oasis for each patient's journey.

Date :
  1. Date Completed 2021-09-16
  2. Date Revised 2021-09-16
Further Info :

Pubmed ID

34521793

DOI: Digital Object Identifier

34521793

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Languages

English

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