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Antimicrobial resistance of Haemophilus influenzae isolates from pediatric hospitals in Mainland China: Report from the ISPED program, 2017-2019.

Author: CaoQing, CaoSancheng, ChenYunsheng, DengHuiling, DengJikui, FangChao, FuPan, GaoWei, HaoJianhua, HuaChunzhen, HuangWeichun, JingChunmei, LinAiwei, ShangShiqiang, WangChuanqing, WangShifu, XuHongmei, YuHui, ZhangHong, ZhangTing, ZhouMingming

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

An antimicrobial resistance surveillance study of 13,810 Haemophilus influenzae isolates from nine pediatric hospitals in mainland China revealed increasing resistance rates to ampicillin and azithromycin. Resistance to sulfamethoxazole-trimethoprim, ampicillin, cefuroxime, ampicillin-sulbactam, and amoxicillin-clavulanate was also high. Third-generation cephalosporins were the preferred treatment option for ampicillin-resistant H. influenzae infections.
Paper Details　
Original Abstract of the Article :
PURPOSE: This study set out to determine the antimicrobial resistance trends of Haemophilus influenzae isolates from pediatric hospitals in Mainland China, which would provide basis for clinical treatment. METHODS: The Infectious Disease Surveillance of Pediatrics (ISPED) collaboration group conduc...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijmmb.2021.09.001

データ提供：米国国立医学図書館（NLM）

Antimicrobial Resistance of Haemophilus influenzae in Pediatric Hospitals in China

In the field of [infectious diseases], understanding [antimicrobial resistance] is crucial for effective treatment. This study investigated the [antimicrobial resistance trends] of [Haemophilus influenzae] isolates collected from pediatric hospitals in Mainland China, providing valuable insights for clinical decision-making. Using the [disk diffusion method], researchers analyzed [antimicrobial susceptibility] of the isolates, shedding light on the evolving landscape of [antimicrobial resistance] in this region.

Significant Resistance Rates and Trends Observed

The study revealed concerning [resistance rates] to various antibiotics, with [63.32% isolates] producing [β-lactamase] and [8.22% isolates] exhibiting [β-lactamase-negative and ampicillin-resistant (BLNAR)] phenotype. Of particular note is the [increasing trend] in [resistance to ampicillin and azithromycin] over the years. These findings underscore the need for ongoing surveillance and monitoring of [antimicrobial resistance] in [pediatric populations] to ensure effective treatment strategies.

Implications for Clinical Practice and Public Health

The study's findings have significant implications for [clinical practice and public health]. Clinicians treating [pediatric patients] with [Haemophilus influenzae] infections should be aware of the rising [antimicrobial resistance] and consider alternative treatment options, such as [third-generation cephalosporins]. The study's results also highlight the importance of [promoting prudent antibiotic use] to mitigate the spread of [antimicrobial resistance].

Dr. Camel's Conclusion

This research is like a desert explorer navigating through a shifting landscape of microbial resistance. The study underscores the importance of understanding and adapting to these ever-changing conditions. The rising resistance rates serve as a reminder that we must continue to be vigilant in our approach to combatting infectious diseases, just as a desert explorer must be prepared for unexpected challenges.
Date :
  1. Date Completed 2021-12-28
  2. Date Revised 2021-12-28
Further Info :

Pubmed ID

34556347

DOI: Digital Object Identifier

10.1016/j.ijmmb.2021.09.001

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Languages

English

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