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Genetic Subtypes and Natural Resistance Mutations in HCV Genotype 4 Infected Saudi Arabian Patients.

Author: AlwazzehMarwan J, Di StefanoMariantonietta, ElaminMohamed O M E, Elmnan AdemSaada A, EltreifiObeidi, FaleoGiuseppina, FioreJose R, IsmailMona H, LeitnerThomas, SantantonioTeresa A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study analyzed the genetic subtypes of hepatitis C virus (HCV) and the presence of resistance-associated substitutions (RASs) in a cohort of Saudi Arabian patients. The findings revealed that GT 4a was the most prevalent subtype, with RASs identified in 35% of patients. While treatment with sofosbuvir plus daclatasvir resulted in sustained virological response (SVR) in most patients, one patient carrying NS3-RAS V170I relapsed.
Paper Details　
Original Abstract of the Article :
This study aimed to characterize the HCV genetic subtypes variability and the presence of natural occurring resistance-associated substitutions (RASs) in Saudi Arabia patients. A total of 17 GT patients were analyzed. Sequence analysis of NS3, NS5A, and NS5B regions was performed by direct sequencin...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472952/

データ提供：米国国立医学図書館（NLM）

HCV Genotype 4 in Saudi Arabian Patients: A Challenging Desert of Resistance

Hepatitis C virus (HCV) is a formidable foe, leaving a trail of liver damage in its wake. This study investigates the genetic subtypes of HCV in Saudi Arabian patients, focusing on genotype 4, a particularly challenging strain. Researchers [研究手法] to analyze the genetic diversity of HCV in this population and identify potential resistance-associated substitutions (RASs). The results provide valuable insights into the genetic landscape of HCV in Saudi Arabia and the potential challenges associated with treatment.

The Evolving Landscape of HCV Resistance

The study found that HCV genotype 4 is the most common subtype in this cohort of Saudi Arabian patients, with various subtypes being identified. [研究結果] These findings underscore the importance of genotype-specific treatment strategies for HCV, considering the potential for resistance to develop. Ongoing surveillance of HCV genotypes and RASs is essential for guiding effective treatment regimens.

Navigating the HCV Desert

This study emphasizes the need for ongoing vigilance in the fight against HCV, especially in the face of evolving resistance patterns. By understanding the genetic diversity of HCV and identifying potential resistance mechanisms, we can develop more effective treatment strategies and improve patient outcomes.

Dr. Camel's Conclusion

The fight against HCV is a challenging journey through a desert of resistance. This study highlights the importance of understanding the genetic diversity of HCV and developing targeted treatments to combat this persistent foe.

Date :
  1. Date Completed 2022-02-01
  2. Date Revised 2022-07-16
Further Info :

Pubmed ID

34578414

DOI: Digital Object Identifier

PMC8472952

Related Literature

Article Analysis
・Effects of daclatasvir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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