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A systematic review and meta-analysis of the efficacy of topical sphincterotomy treatments for anal fissure.

Author: ConnollyAndrew, HardyMolly-Olivia, HillAndrew G, JinJames Z, Mauiliu-WallisMelbourne, SinghPrimal Parry, UnasaHanson, WestonMaree

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Topical nitrates (glyceryl trinitrate [GTN]) were more effective than placebo in healing anal fissures, with a relative risk (RR) of 1.96 (95% CI 1.35-2.84). GTN also reduced pain but was associated with a higher risk of headache. More evidence is needed to determine the effectiveness of topical diltiazem.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Anal fissure is a common condition that can be treated medically or surgically. Chemical sphincterotomy is often used before surgical intervention. This study aims to evaluate the effectiveness of topical agents for chemical sphincterotomy on healing of anal fissures and side-effects. M...See full text at original site
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引用元：
https://doi.org/10.1007/s00384-021-04040-3

データ提供：米国国立医学図書館（NLM）

Evaluating Topical Sphincterotomy Treatments for Anal Fissure

Anal fissure, a painful tear in the lining of the anus, is like a crack in a desert oasis, causing discomfort and disruption. Topical sphincterotomy treatments, which relax the muscles around the anus, are often used to treat anal fissures. Imagine these treatments as a gentle desert wind, easing the tension and allowing the crack to heal. This study reviews the evidence on topical sphincterotomy agents, comparing their effectiveness and side effects. The researchers analyzed data from 37 randomized controlled trials, like conducting experiments in different desert environments, to compare the effectiveness of different topical agents. They found that glyceryl trinitrate (GTN) was more effective than placebo in healing anal fissures, but it also had a higher risk of headaches. Diltiazem, another commonly used agent, showed mixed results.

Healing the Cracks in the Desert: Evaluating Topical Treatments for Anal Fissure

The study suggests that while topical sphincterotomy treatments can be effective in healing anal fissures, the choice of agent and the potential risks and benefits should be carefully considered for each patient. It's like choosing the right desert plant to help heal a crack in the oasis, considering the specific needs of the oasis and the potential effects of the plant.

Dr. Camel's Conclusion

This review provides valuable guidance for treating anal fissure, a condition that can disrupt everyday life. By understanding the different treatment options and their potential risks and benefits, we can choose the best approach to help heal the cracks in the desert of our bodies.

Date :
  1. Date Completed 2022-01-18
  2. Date Revised 2022-01-18
Further Info :

Pubmed ID

34608561

DOI: Digital Object Identifier

10.1007/s00384-021-04040-3

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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