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Therapeutic Drug Monitoring of Ganciclovir: Where Are We?
Author: AlffenaarJan-Willem C, EdwinaAngela E, KimHannah Yejin, KnoesterMarjolein, MärtsonAnne-Grete, SturkenboomMarieke G G, TouwDaan J
Original Abstract of the Article :
Ganciclovir is the mainstay of therapy for the prophylaxis and treatment of Cytomegalovirus. However, therapy with this antiviral agent is hindered by side effects such as myelosuppression, which often leads to therapy cessation. Underdosing, as an attempt to prevent side effects, can lead to drug r...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746890/
データ提供:米国国立医学図書館(NLM)
Ganciclovir Therapeutic Drug Monitoring: A Balancing Act
The field of [antiviral therapy] is constantly evolving, and this research delves into the important issue of [therapeutic drug monitoring] for [ganciclovir], a key medication in the fight against [cytomegalovirus]. The researchers employed a [narrative review] approach to provide a comprehensive overview of [ganciclovir TDM], including [available assays], [population pharmacokinetic models], and [current knowledge gaps]. Their findings shed light on the challenges of balancing the benefits and risks of [ganciclovir therapy], especially in the context of [myelosuppression] and [drug resistance].
Finding the Right Dose: A Balancing Act
The study reveals that [ganciclovir TDM] is a valuable tool in optimizing [ganciclovir therapy]. It helps to identify the optimal dose for each patient, minimizing the risk of [side effects] while ensuring effective [viral suppression]. The study highlights the importance of individualized therapy, emphasizing that a one-size-fits-all approach may not be suitable for all patients.
Navigating the Sands of Ganciclovir Therapy
The researchers emphasize the need for more research to address the [current knowledge gaps] in [ganciclovir TDM]. This includes developing more [accurate and efficient assays] and improving our understanding of [pharmacokinetic variability]. These advancements could lead to even more effective and personalized treatments for [cytomegalovirus] infection, minimizing the risk of [complications] and improving patient outcomes.
Dr.Camel's Conclusion
This research highlights the importance of [therapeutic drug monitoring] in [antiviral therapy]. It’s like navigating a vast desert – you need to carefully adjust your course based on the terrain and resources available. By carefully monitoring [ganciclovir] levels, we can ensure that patients receive the optimal dose for their needs. This is crucial for minimizing the risk of [side effects] and maximizing the efficacy of treatment. It’s a reminder that even in the age of advanced medicine, finding the right balance is key to successful outcomes.
Date :
- Date Completed 2022-03-23
- Date Revised 2023-11-05
Further Info :
Related Literature
English
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