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Therapeutic Potential of Indole Derivatives as Anti-HIV Agents: A Mini-review.

Author: ChenQingtai, LiEnzhong, WuChongchong, XuZhi, ZhuJinjin

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This review focuses on the recent advancement in indole derivatives with anti-HIV potential. The review covers articles published between 2010 and 2020, discussing the chemical structures, structure-activity relationship, and mechanisms of action of indole derivatives as inhibitors of HIV enzymes.
Paper Details　
Original Abstract of the Article :
Acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency virus (HIV), is one of the leading causes of human deaths. The advent of different anti-HIV drugs has turned AIDS/HIV from a deadly infection to chronic and manageable disease. However, the development of multidrug-resis...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.2174/1568026621666211012111901

データ提供：米国国立医学図書館（NLM）

Indole Derivatives: New Hope in the Desert of HIV

The battle against HIV is a continuous journey across the vast desert of research and development. New and effective therapies are constantly being sought to combat this deadly virus. This review explores the potential of indole derivatives, a class of chemical compounds, as anti-HIV agents. The authors highlight the promising potential of indole derivatives to inhibit key HIV enzymes, offering hope for new therapeutic strategies.

Indole Derivatives: A New Oasis in the Desert of HIV

The review focuses on the recent advancements in indole derivatives, including indole alkaloids, hybrids, and dimers with anti-HIV potential. The authors discuss the chemical structures, structure-activity relationships, and mechanisms of action of these compounds, providing valuable insights for researchers and clinicians working in the field of HIV treatment.

Navigating the Desert with Indole Derivatives

The development of multidrug-resistant viruses and the severe side effects of existing anti-HIV agents have created a challenging landscape for HIV treatment. Indole derivatives offer a promising new approach, with their ability to inhibit key HIV enzymes. This review provides a valuable resource for understanding the potential of these compounds and guiding future research and development efforts.

Dr.Camel's Conclusion

The desert of HIV is a harsh and relentless environment, but with the development of innovative therapies like indole derivatives, we can create new oases of hope for those living with this devastating disease. This review highlights the promising potential of these compounds and the importance of continued research to combat HIV and improve the lives of those affected.

Date :
  1. Date Completed 2022-07-29
  2. Date Revised 2022-07-29
Further Info :

Pubmed ID

34636313

DOI: Digital Object Identifier

10.2174/1568026621666211012111901

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