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Green synthesized colloidal silver is devoid of toxic effects on primary human nasal epithelial cells in vitro.

Author: CooksleyClare M, FeiziSholeh, JavadiyanShari, PsaltisAlkis James, ShaghayeghGohar, VreugdeSarah, WormaldPeter-John

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study examines the safety of green synthetized colloidal silver (GSCS) on the structure and function of the human nasal epithelial barrier. The GSCS was applied to primary human nasal epithelial cells grown in an air-liquid interface culture. While a slight decrease in the transepithelial electrical resistance was observed, no significant changes in paracellular permeability, cell viability, inflammation, or ciliary beat frequency were detected. This suggests that GSCS does not have toxic effects on human nasal epithelial cells.
Paper Details　
Original Abstract of the Article :
Evaluating the safety of previously fabricated and effective green synthetized colloidal silver (GSCS) on the mucosal barrier structure and function is essential prior to conduct human trials. The GSCS was applied to primary human nasal epithelial cells (HNECs) grown in an air-liquid interface (ALI)...See full text at original site
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引用元：
https://doi.org/10.1016/j.fct.2021.112606

データ提供：米国国立医学図書館（NLM）

The Safety of Colloidal Silver: A Desert Oasis of Caution

In the vast desert of [nanotechnology] applications, researchers are constantly exploring new uses for [colloidal silver], a substance with a long history of applications. This research focuses on the safety of [green synthetized colloidal silver (GSCS)] for use in [nasal epithelial cells], examining its potential impact on the delicate mucosal barrier. The authors conducted a series of [in vitro] experiments to assess the safety of [GSCS] on [primary human nasal epithelial cells (HNECs)].

A Safe Oasis: A Desert of Potential

The research demonstrates the safety of [GSCS] for use in [HNECs], providing a potential oasis in the desert of potential applications for this material. The authors found that [GSCS] did not cause significant damage to [HNECs], indicating its potential for safe use in [nasal epithelial cells].

Navigating the Desert: A Cautious Approach

The authors acknowledge the importance of further research to fully understand the safety of [GSCS] in different settings. Just as a wise desert traveler navigates carefully, researchers need to proceed with caution when exploring the potential applications of this material.

Dr.Camel's Conclusion

The desert of [nanotechnology] applications is vast and full of potential. This research sheds light on the safety of [GSCS] for use in [nasal epithelial cells], providing a potential oasis of safety in this vast landscape. As we continue to explore the potential of [nanotechnology], it is important to proceed with caution and a clear understanding of the risks and benefits involved.

Date :
  1. Date Completed 2022-02-09
  2. Date Revised 2022-02-09
Further Info :

Pubmed ID

34653555

DOI: Digital Object Identifier

10.1016/j.fct.2021.112606

Related Literature

Article Analysis
・Effective treatment of colloidal silver
SNS
PICO Info
in preparation
Languages

English

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