Combined cART including Tenofovir Disoproxil, Emtricitabine, and Dolutegravir has potent therapeutic effects in HIV-1 infected humanized mice.

Author: AfframYvonne, BenedettiFrancesca, BryantJoseph, DenaroFrank, HerediaAlonso, LatinovicOlga S, MunawwarArshi, RamadhaniHabib O, ReitzMarvin, Rikhtegaran-TehraniZahra, RomerioFabio, SajadiMohammad M, TagayaYutaka, WeichseldorferMatthew, WilliamsSumiko P, ZellaDavide

Paper Details 
Original Abstract of the Article :
HIV-1 reservoirs persist in the presence of combined antiretroviral therapy (cART). However, cART has transformed HIV-1 infection into a chronic disease marked by control of HIV-1 viral load and mortality reduction. Major challenges remain, including viral resistance upon termination of cART and per...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557591/

データ提供:米国国立医学図書館(NLM)

Combating HIV: A Powerful Drug Combination Shows Promise

Infectious disease research continues to seek new and effective treatments for HIV infection. This study examines the effectiveness of a particular combination of antiretroviral medications, including tenofovir disoproxil (TDF), emtricitabine (FTC), and dolutegravir (DTG), in humanized mice. The researchers analyzed the impact of this drug combination on viral suppression and identified potential sites of HIV-1 reservoir persistence.

A Powerful Combination: Suppression of HIV Viral Load

The study found that this combination of antiretroviral medications was highly effective in suppressing HIV viral load in humanized mice. The study also identified potential sites of HIV-1 reservoir persistence, suggesting that ongoing research into eradication strategies is crucial. This drug combination is a valuable tool in the fight against HIV, offering hope for patients seeking long-term viral suppression and improved health outcomes.

Living with HIV: Hope for the Future

This study highlights the progress made in the development of effective HIV treatments, but it also underscores the importance of ongoing research to find a cure. While current treatments are effective in managing HIV infection, the persistence of HIV reservoirs poses a challenge to eradication. Further research into strategies for eliminating these reservoirs is crucial to achieve a cure for HIV.

Dr.Camel's Conclusion

Just like a camel traversing a vast and unforgiving desert, scientists are constantly seeking new ways to combat the challenges of HIV infection. This study highlights the effectiveness of a potent drug combination in suppressing viral load, offering hope for a future where HIV is no longer a life-limiting disease.

Date :
  1. Date Completed 2021-12-08
  2. Date Revised 2022-11-17
Further Info :

Pubmed ID

34717655

DOI: Digital Object Identifier

PMC8557591

Related Literature

SNS
PICO Info
in preparation
Languages

English

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