Effects of Maternal Fenbendazole on Litter Size, Survival Rate, and Weaning Weight in C57BL/6J Mice.

Author: HicksKristina L, LindstromKrista E, RocheElysia, WilkersonJames D

Paper Details 
Original Abstract of the Article :
Fenbendazole is a broad-spectrum benzimidazole commonly used in laboratory animal medicine as an anthelmintic for elimination of pinworms. This drug is generally regarded as safe, with minimal side effects. Some data in rodent species indicate multiple physiologic effects of fenbendazole, including ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628531/

データ提供:米国国立医学図書館(NLM)

Fenbendazole's Impact on Reproduction in Mice: A Camel's Journey Through the Desert of Reproduction

The field of reproductive biology is a vast and intricate desert, where researchers strive to understand the complex interplay of factors that influence fertility. This study focuses on fenbendazole, a commonly used anthelmintic drug, and its potential effects on reproduction in mice. The researchers conducted a comprehensive study investigating the effects of various fenbendazole treatment regimens on litter size, survival rate, and weaning weight. Their findings provide valuable insights into the drug's impact on reproductive parameters in mice.

Fenbendazole's Unremarkable Impact on Reproduction

The study found no significant differences in litter size, survival rate, or weaning weight between mice treated with fenbendazole and those in the control group. This finding suggests that under the specific conditions of the study, fenbendazole does not have a detrimental effect on reproduction in mice. It's like a oasis in the desert of reproductive research, offering reassurance about the drug's potential impact on fertility.

Fenbendazole and Reproductive Health

This research contributes to our understanding of fenbendazole's safety profile, providing valuable information for clinicians and researchers working with mice. The study's findings suggest that fenbendazole may not pose a significant risk to reproduction in mice. However, further research is needed to explore the potential impact of fenbendazole on reproduction in other animal models and to determine if there are any long-term effects on offspring.

Dr. Camel's Conclusion

This study provides valuable insights into the effects of fenbendazole on reproduction in mice, offering reassurance about its potential impact on fertility. While further research is needed to fully understand the drug's long-term effects, this study serves as a beacon of hope in the desert of reproductive biology, suggesting that fenbendazole may not pose a significant threat to fertility in mice. The journey to understand the complex world of reproduction continues, and this research provides a valuable stepping stone on that path.

Date :
  1. Date Completed 2021-12-06
  2. Date Revised 2022-05-03
Further Info :

Pubmed ID

34753534

DOI: Digital Object Identifier

PMC8628531

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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