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D-penicillamine effects on prostanoid production in adherent rheumatic synovial cells in primary culture.

Author: MoilanenE, NissiläM, SeppäläE, VapaataloH

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

D-penicillamine (DPA), an antirheumatic drug, was found to increase levels of prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) and reduce levels of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) in a primary culture of synovial cells from patients with rheumatoid arthritis.
Paper Details　
Original Abstract of the Article :
The effect of D-penicillamine (DPA) on immunoreactive prostanoid concentrations was studied in a primary culture of adherent synovial cells from patients suffering from rheumatoid arthritis (RA). DPA in clinically achievable concentrations increased the levels of prostaglandin E2 (PGE2) and thrombox...See full text at original site
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引用元：
https://doi.org/10.1016/0262-1746(87)90159-4

データ提供：米国国立医学図書館（NLM）

D-Penicillamine's Impact on Prostanoid Production in Rheumatoid Arthritis

This study delves into the complex world of [rheumatoid arthritis (RA)], investigating the effects of [D-penicillamine (DPA)] on [prostanoid] production in synovial cells. The researchers explored the impact of DPA on the production of various prostanoids, key signaling molecules involved in inflammation.

DPA's Influence on Prostanoid Production: A Complex Interaction

The study revealed that DPA, at clinically relevant concentrations, influences prostanoid production in RA synovial cells, leading to an increase in PGE2 and TXB2 and a decrease in 6-keto-PGF1 alpha. This complex interplay of prostanoids could contribute to DPA's antirheumatic and immunosuppressive effects.

Navigating the Desert of RA: Understanding Prostanoids and D-Penicillamine

Imagine the inflammatory process in RA as a raging desert sandstorm, with prostanoids acting as powerful winds. This study explores how DPA might influence these winds, potentially contributing to its therapeutic effects in managing RA.

Dr.Camel's Conclusion

This research sheds light on the complex interplay of DPA and prostanoids in RA. It underscores the importance of understanding these interactions for developing effective treatments and managing this challenging autoimmune condition.

Date :
  1. Date Completed 1987-10-14
  2. Date Revised 2019-10-29
Further Info :

Pubmed ID

3476966

DOI: Digital Object Identifier

10.1016/0262-1746(87)90159-4

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Languages

English

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