A narrative review on adverse effects of dasatinib with a focus on pharmacotherapy of dasatinib-induced pulmonary toxicities.

Author: MoghimiMinoo, NekoukarZahra, SalehifarEbrahim

Paper Details 
Original Abstract of the Article :
Chronic myeloid leukemia (CML), a myeloproliferative disorder caused by the over activity of BCR-ABL1 (breakpoint cluster region-Abelson), has been successfully treated by Tyrosine kinase inhibitors (TKIs). While imatinib is known as the first-line treatment of CML, in some cases other TKIs includin...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721448/

データ提供:米国国立医学図書館(NLM)

Dasatinib's Pulmonary Complications: A Closer Look

The treatment of chronic myeloid leukemia (CML) has significantly advanced with the introduction of tyrosine kinase inhibitors (TKIs), offering hope for patients with this life-threatening disease. This study focuses on the potential pulmonary complications associated with dasatinib, a second-generation TKI, and explores strategies for managing these adverse effects. The researchers, like explorers venturing into the unknown, seek to understand the complexities of dasatinib-induced pulmonary toxicities and provide insights into appropriate management.

The study highlights the efficacy of dasatinib in treating CML, particularly in cases resistant to imatinib. However, the researchers emphasize the potential for dasatinib to cause serious pulmonary complications, including pleural effusion (PE) and pulmonary arterial hypertension (PAH). The study underscores the importance of early detection and prompt management of these adverse effects to minimize the impact on patient health and quality of life.

Navigating the Side Effects of Dasatinib

This research provides a valuable guide for healthcare professionals managing patients receiving dasatinib therapy. It emphasizes the importance of careful monitoring for potential pulmonary complications and outlines strategies for managing these adverse effects.

Prioritizing Patient Well-being

This study underscores the importance of prioritizing patient well-being throughout the course of treatment. Just as a camel adapts to the harsh desert environment, patients receiving dasatinib therapy may require adjustments to their treatment plans to minimize the risk of adverse effects. This research highlights the need for a collaborative approach between healthcare providers and patients, ensuring that treatment decisions are made in the best interests of the individual patient.

Dr. Camel's Conclusion

This study is like a compass guiding us through the complexities of dasatinib therapy. It reveals the potential for pulmonary complications, but also emphasizes the importance of early detection and proactive management. As a researcher who has witnessed the remarkable progress made in CML treatment, I am committed to ensuring that these advancements are accompanied by a focus on patient well-being. This research serves as a reminder that even in the face of progress, we must remain vigilant in monitoring and addressing the potential risks associated with therapies.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-03
Further Info :

Pubmed ID

34776414

DOI: Digital Object Identifier

PMC8721448

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.