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Effects of paeoniflorin-6'-O-benzene sulfonate on the pharmacokinetics, excretion and tissue distribution of leflunomide in rats.

Author: GaoJinzhang, KuaiJiajie, WangChun, WangQianlei, WeiWei, XiaoFeng, XiaoNing, XuZhengkun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Paeoniflorin-6'-O-benzene sulfonate (CP-25), a derivative of paeoniflorin, has synergistic effects with leflunomide (LEF) in treating rheumatoid arthritis. This study investigated the effect of CP-25 on LEF pharmacokinetics in rats. It found that CP-25 increased LEF excretion and reduced its concentration in most tissues, potentially mitigating LEF-induced liver injury. CP-25 also enhanced LEF accumulation in synovial tissues and uptake by peripheral blood mononuclear cells, potentially explaining its synergistic effects with LEF.
Paper Details　
Original Abstract of the Article :
Paeoniflorin-6'-O-benzene sulfonate (CP-25) is a novel ester derivative of paeoniflorin, which has been shown to have synergistic pharmacodynamic effects with leflunomide (LEF). To determine the effects of CP-25 on the pharmacokinetics of LEF in rats, we developed a ultra-high performance liquid chr...See full text at original site
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引用元：
https://doi.org/10.1111/bcpt.13685

データ提供：米国国立医学図書館（NLM）

Paeoniflorin-6'-O-benzene Sulfonate: A Synergistic Partner for Leflunomide

This research delves into the potential synergistic effects of Paeoniflorin-6'-O-benzene sulfonate (CP-25) in combination with leflunomide (LEF). Imagine a camel caravan traversing a challenging desert landscape, where the combined efforts of different camels can overcome obstacles that would be insurmountable alone. The study investigates the effects of CP-25 on the pharmacokinetics, excretion, and tissue distribution of LEF in rats, exploring the possibility of enhanced therapeutic efficacy.

CP-25 and LEF: A Powerful Duo for Treatment

The study suggests that CP-25 may enhance the efficacy of LEF by altering its pharmacokinetics and tissue distribution. It's like a camel caravan utilizing the strengths of different camels to navigate challenging terrain. The researchers observe that CP-25 promotes the excretion of LEF's active metabolite, teriflunomide (TER), while increasing its concentration in the synovium and its absorption by peripheral blood mononuclear cells (PBMCs), potentially contributing to synergistic therapeutic effects.

A New Path Towards More Effective Treatment

This research offers exciting possibilities for improving the treatment of certain conditions. Just as a camel caravan utilizes a diverse array of camels for optimal performance, so too might the combination of drugs like CP-25 and LEF offer a more effective therapeutic approach. The study's findings suggest a promising avenue for future research and development of more effective treatment strategies.

Dr.Camel's Conclusion

The search for synergistic drug combinations is a continuous journey, much like a camel caravan seeking the most effective route across a vast and challenging desert. This research offers a promising example of how combining different therapeutic agents can potentially lead to enhanced efficacy and improved outcomes for patients.

Date :
  1. Date Completed 2022-04-04
  2. Date Revised 2022-04-05
Further Info :

Pubmed ID

34792845

DOI: Digital Object Identifier

10.1111/bcpt.13685

Related Literature

Article Analysis
・Effects of leflunomide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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