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Cardioprotective effects of bosentan in 5-fluorouracil-induced cardiotoxicity.

Author: Abdel-GaberSeham A, HafezSara Mohamed Naguib Abdel, KhalafHanaa Mohamed, RahmanSara Awad Abd El, RefaieMarwa M M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

5-fluorouracil (5-FU), a widely used chemotherapy drug, can cause cardiotoxicity. This study demonstrates that bosentan, an endothelin receptor antagonist, can effectively protect against 5-FU-induced cardiac damage in rats. The protective effects are likely due to bosentan's ability to inhibit endothelin receptors, stimulate nitric oxide production, and possess anti-oxidant, anti-inflammatory, and anti-apoptotic properties.
Paper Details　
Original Abstract of the Article :
5-fluorouracil (5-FU) is a widely used chemotherapeutic agent but cardiotoxicity challenges its clinical usefulness. Thus, searching for more cardioprotective drugs is highly required to prevent the accompanied cardiac hazards. Up to date, the different mechanisms involved in 5-FU cardiotoxicity are...See full text at original site
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引用元：
https://doi.org/10.1016/j.tox.2021.153042

データ提供：米国国立医学図書館（NLM）

Cardioprotective Effects of Bosentan in 5-Fluorouracil-Induced Cardiotoxicity

This study explores the intricate relationship between chemotherapy and cardiovascular health, specifically examining the cardioprotective effects of bosentan, a drug used to treat pulmonary arterial hypertension, in rats experiencing 5-fluorouracil (5-FU)-induced cardiotoxicity. 5-FU is a widely used chemotherapy drug, but its potential to cause heart damage limits its clinical use. This study aims to investigate the ability of bosentan to mitigate these cardiac hazards.

Bosentan: A Potential Shield Against 5-FU Cardiotoxicity

The researchers found that bosentan significantly ameliorated 5-FU-induced cardiotoxicity in rats, reducing markers of cardiac injury and inflammation. They also observed that bosentan modulated the TLR4/MyD88/NFκB signaling pathway, a key pathway involved in inflammation and cell death. This suggests that bosentan's cardioprotective effect might stem from its ability to inhibit the inflammatory response triggered by 5-FU. Imagine the heart as a fragile oasis in the harsh desert of chemotherapy-induced toxicity. Bosentan, like a protective barrier, helps shield the heart from the damaging effects of 5-FU, reducing the risk of cardiac injury.

A Promising Avenue for Protecting the Heart

This study offers a promising avenue for protecting the heart during 5-FU chemotherapy. The researchers demonstrate that bosentan can effectively mitigate 5-FU-induced cardiotoxicity, suggesting that this drug could be a valuable tool for managing the cardiovascular risks associated with chemotherapy. Just as a desert traveler seeks shelter from the scorching sun, so too do patients undergoing chemotherapy need protection from the potential heart damage associated with these treatments.

Dr.Camel's Conclusion

This research explores the cardioprotective effects of bosentan in 5-fluorouracil (5-FU)-induced cardiotoxicity. The researchers demonstrate that bosentan effectively mitigates 5-FU-induced cardiac damage, offering a potential strategy for managing the cardiovascular risks associated with chemotherapy. This study reminds us that the desert of chemotherapy is not without its dangers, but with careful navigation and the right tools, we can minimize the risks and ensure the well-being of our patients.

Date :
  1. Date Completed 2022-02-21
  2. Date Revised 2022-02-21
Further Info :

Pubmed ID

34800596

DOI: Digital Object Identifier

10.1016/j.tox.2021.153042

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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