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Epigenetic Therapy Augments Classic Chemotherapy in Suppressing the Growth of 3D High-Grade Serous Ovarian Cancer Spheroids over an Extended Period of Time.

Author: AikinsJames K, BilbaoMichelle, HunterKrystal, KassStephanie L, KatzChelsea, OstrovskyOlga, SmithDevon, WarshalDavid

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

In a 3D spheroid model of recurrent high-grade serous ovarian cancer, panobinostat, an epigenetic therapy, effectively reversed the exponential growth induced by paclitaxel, a classic chemotherapy drug. This finding highlights the potential of epigenetic therapy in overcoming chemotherapy resistance in recurrent ovarian cancer.
Paper Details　
Original Abstract of the Article :
Recurrent high-grade serous ovarian cancer (HGSC) is clinically very challenging and prematurely shortens patients' lives. Recurrent ovarian cancer is characterized by high tumor heterogeneity; therefore, it is susceptible to epigenetic therapy in classic 2D tissue culture and rodent models. Unfortu...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615646/

データ提供：米国国立医学図書館（NLM）

Epigenetic Therapy: A Promising New Strategy for Recurrent High-Grade Serous Ovarian Cancer

This research investigates the [Efficacy of Epigenetic Therapy] in combination with [Classic Chemotherapy] for [Recurrent High-Grade Serous Ovarian Cancer]. It utilizes a [3D Spheroid Model] to assess the long-term effects of these treatments. The authors demonstrate the [Superiority of Epigenetic Therapy] over [Paclitaxel Alone] in suppressing cancer cell growth. This study sheds light on the potential of [Epigenetic Modulation] as a new therapeutic approach for ovarian cancer.

Reversing the Tides of Cancer Growth

This research reveals the [Potential of Epigenetic Therapy] to [Reverse the growth-promoting effects] of classic chemotherapy. The study found that [Panobinostat significantly reduced cancer cell repopulation] following paclitaxel treatment, suggesting a synergistic effect. This finding opens new avenues for [Developing more effective therapies] for recurrent ovarian cancer.

Hope for Patients with Recurrent Ovarian Cancer

This research offers [Hope for patients with recurrent ovarian cancer], suggesting that [Epigenetic therapy may provide a more durable response] compared to conventional chemotherapy. This study emphasizes the [Importance of exploring new treatment modalities] to address the challenges of this difficult-to-treat cancer. It encourages [Further research] to fully understand the potential of epigenetic therapy in treating ovarian cancer.

Dr. Camel's Conclusion

This research offers a beacon of hope for patients with recurrent ovarian cancer. Just as a camel can navigate the toughest terrains, this research reveals a promising new path in the fight against this devastating disease. The study demonstrates the potential of epigenetic therapy to enhance treatment outcomes, paving the way for more effective and personalized therapies for ovarian cancer.

Date :
  1. Date Completed 2022-01-12
  2. Date Revised 2022-01-12
Further Info :

Pubmed ID

34827710

DOI: Digital Object Identifier

PMC8615646

Related Literature

Article Analysis
・Effects of panobinostat
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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