Paper Details

  1. Home
  2. Paper Details

Evidence of off-target effects of bosutinib that promote retinoic acid-induced differentiation of non-APL AML cells.

Author: KazimNoor, YenAndrew

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of Bosutinib, a Src family kinase (SFK) inhibitor, and Lyn SFK knockdown on all-trans retinoic acid (RA)-induced leukemia cell differentiation. Bosutinib and Lyn knockdown both enhanced RA-induced differentiation, cell cycle arrest, and respiratory burst in HL-60 cells. While neither approach affected key signaling events involved in RA-induced differentiation, Bosutinib still promoted differentiation even in the absence of Lyn. This suggests a novel, off-target, Lyn-independent mechanism of action for Bosutinib, potentially offering new therapeutic strategies for leukemia treatment.
Paper Details　
Original Abstract of the Article :
In the present study, we determined the effects of the Src family kinase (SFK) inhibitor, Bosutinib, and the engineered loss of the Lyn SFK on all-trans retinoic acid-induced leukemic cell differentiation. Retinoic acid (RA) is an embryonic morphogen and dietary factor that demonstrates chemotherape...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726618/

データ提供：米国国立医学図書館（NLM）

Unveiling the Hidden Oasis: Bosutinib's Off-Target Effects in AML Treatment

Imagine a desert landscape of leukemia cells, where the challenge lies in finding ways to control their relentless growth. This study explores the potential of bosutinib, a Src family kinase (SFK) inhibitor, to promote the differentiation of leukemia cells, a process that can help to control cancer growth. Researchers are like explorers seeking a hidden oasis in this desert, searching for new ways to manipulate cellular processes for therapeutic benefit.

Unlocking the Potential of Bosutinib: A New Approach to AML Treatment

The study found that bosutinib, in addition to its known SFK inhibitory effects, had unexpected, but potentially beneficial, off-target effects. These off-target effects promoted the differentiation of leukemia cells in response to retinoic acid, a powerful agent known to induce cell differentiation. This finding suggests that bosutinib might be a valuable tool for treating leukemia, not only by directly inhibiting cancer cell growth, but also by promoting their differentiation into less harmful cell types.

A Hidden Oasis in the Desert: Exploring the Potential of Off-Target Effects

This study highlights the importance of exploring the full potential of drug molecules, including their unexpected off-target effects. These off-target effects, which are often overlooked, may hold the key to new and innovative therapeutic strategies. The study emphasizes the need for comprehensive research to understand the full range of drug effects and maximize their potential for treating complex diseases.

Dr. Camel's Conclusion

This study, like a caravan discovering a hidden oasis in the desert, unveils the surprising off-target effects of bosutinib in promoting leukemia cell differentiation. This finding opens a new avenue for exploring the potential of this drug in the treatment of AML. The study also emphasizes the importance of recognizing the potential of off-target effects in drug discovery, as these unexpected pathways might hold the key to new therapeutic breakthroughs.

Date :
  1. Date Completed 2022-04-07
  2. Date Revised 2022-11-27
Further Info :

Pubmed ID

34836491

DOI: Digital Object Identifier

PMC8726618

Related Literature

Article Analysis
・Effects of bosutinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.