Paper Details

  1. Home
  2. Paper Details

Oligonucleotides Carrying Nucleoside Antimetabolites as Potential Prodrugs.

Author: AviñóAnna, CluaAnna, EritjaRamon, FàbregaCarme

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Oligonucleotides modified with nucleoside antimetabolites offer a promising prodrug strategy for delivering chemotherapy drugs. This approach utilizes enzymatic degradation within cells to release active nucleotides, minimizing side effects. Current research focuses on improving the antiproliferative properties of nucleoside homopolymers, as well as utilizing aptamers, antisense oligonucleotides, and siRNA carrying antiproliferative nucleotides.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Nucleoside and nucleobase antimetabolites are an important class of chemotherapeutic agents for the treatment of cancer as well as other diseases. INTRODUCTION: In order to avoid undesirable side effects, several prodrug strategies have been developed. In the present review, we describe...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.2174/0929867328666211129124039

データ提供：米国国立医学図書館（NLM）

Oligonucleotides as Potential Prodrugs: A New Frontier in Cancer Treatment

The fight against cancer is constantly evolving, with researchers exploring new therapeutic strategies. This study delves into the potential of oligonucleotide-based prodrugs, which carry nucleoside antimetabolites as active agents. The authors examine the advantages of this approach, including the ability to target specific cells and reduce side effects. The study highlights the growing field of oligonucleotide-based therapies and their potential impact on cancer treatment.

Oligonucleotides: A Promising Avenue for Cancer Therapy

The study presents a compelling case for the development of oligonucleotide-based prodrugs for cancer treatment. The approach offers several advantages, including the ability to deliver active agents directly to target cells, minimize side effects, and potentially improve therapeutic efficacy. This strategy opens new avenues for combating cancer and represents a significant advancement in the field of cancer research.

Navigating the Desert of Cancer Treatment

The search for effective cancer treatments is a continuous journey through a vast and challenging desert. This study highlights the potential of oligonucleotide-based prodrugs as a promising oasis, offering a new approach to fighting cancer with improved efficacy and reduced side effects. This innovative strategy represents a significant step forward in our quest to conquer this complex disease.

Dr.Camel's Conclusion

The development of oligonucleotide-based prodrugs for cancer treatment is an exciting frontier in cancer research. This approach offers a promising avenue for improving therapeutic efficacy and minimizing side effects, potentially transforming the landscape of cancer treatment. It is like finding a hidden oasis in the vast desert of cancer research, offering hope for a brighter future for those affected by this devastating disease.

Date :
  1. Date Completed 2023-03-07
  2. Date Revised 2023-03-07
Further Info :

Pubmed ID

34844535

DOI: Digital Object Identifier

10.2174/0929867328666211129124039

Related Literature

Article Analysis
・Effects of floxuridine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.