Paper Details

  1. Home
  2. Paper Details

A Novel Dibenzoxazepine Attenuates Intracellular Salmonella Typhimurium Oxidative Stress Resistance.

Author: ChiuHao-Chieh, ChouShih-Hsiu, HsuCheng-Yun, LinHsueh-Chun, LinMan-Yi, ShiauChung-Wai, WuYi-Lun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study identifies a novel antibacterial agent, SW14, derived from loxapine, an antipsychotic drug. SW14 effectively suppresses intracellular Salmonella in macrophages, including multidrug-resistant strains. The study investigates the mechanism of action, suggesting that SW14 targets bacterial resistance to host oxidative-stress defense. This finding provides a promising avenue for developing new therapeutics against multidrug-resistant Salmonella infections.
Paper Details　
Original Abstract of the Article :
Salmonella enterica serovar Typhimurium is the leading cause of invasive nontyphoidal salmonellosis. Additionally, the emergence of multidrug-resistant S. Typhimurium has further increased the difficulty of controlling its infection. Previously, we showed that an antipsychotic drug, loxapine, suppre...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635125/

データ提供：米国国立医学図書館（NLM）

Combating the Desert of Antibiotic Resistance: A Novel Dibenzoxazepine Against Salmonella

Salmonella Typhimurium is a formidable foe, like a sandstorm sweeping across the body and causing illness. The emergence of antibiotic-resistant strains has created a vast desert of treatment options for this pathogen. This study delves into the potential of a novel dibenzoxazepine, SW14, as a weapon against intracellular Salmonella Typhimurium. The researchers developed SW14 as a derivative of the antipsychotic drug loxapine and explored its effectiveness against Salmonella within macrophages. They discovered that SW14 effectively suppresses intracellular Salmonella, even in multidrug-resistant strains. This research is an exciting development in the fight against antibiotic resistance, suggesting a new approach for controlling this prevalent pathogen.

A Oasis in the Desert: SW14 Offers Hope Against Antibiotic Resistance

The findings of this study suggest that SW14 could offer a valuable new weapon in the battle against antibiotic-resistant Salmonella Typhimurium. The research provides a glimmer of hope for those struggling with this challenging infection.

Staying Hydrated: Maintaining Antibiotic Effectiveness

This study underscores the importance of ongoing research and development in the fight against antibiotic resistance. By exploring new approaches and potential targets, we can work towards maintaining the effectiveness of antibiotics, ensuring they remain a valuable tool in our arsenal against infectious diseases.

Dr. Camel's Conclusion

The desert of antibiotic resistance is a formidable challenge, but this study offers a promising oasis in the form of SW14. This research provides a valuable contribution to the ongoing quest for new ways to combat antibiotic resistance, and it highlights the importance of ongoing research and development in this critical area.

Date :
  1. Date Completed 2022-02-21
  2. Date Revised 2022-02-21
Further Info :

Pubmed ID

34851152

DOI: Digital Object Identifier

PMC8635125

Related Literature

Article Analysis
・Effects of loxapine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.