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Bone mineral density, kidney function and participant-reported outcome measures in women who switch from tenofovir disoproxil emtricitabine and a nonnucleoside reverse transcriptase inhibitor to abacavir, lamivudine and dolutegravir.

Author: , BarbiniBirgit, CampbellLucy, FoxJulie, GilleeceYvonne, IbrahimFowzia, OrkinChloe, PostFrank A, SamarawickramaAmanda, TariqShema, WatersLaura

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study looked at changes in bone density in women who switched from tenofovir disoproxil fumarate (TDF) to abacavir. The study found that switching to abacavir did not lead to any significant changes in bone density.
Paper Details　
Original Abstract of the Article :
Tenofovir disoproxil fumarate (TDF) is associated with reduced bone mineral density (BMD). The aim of the study was to evaluate changes in BMD in women who switched from TDF, emtricitabine and a nonnucleoside reverse transcriptase inhibitor (TDF/FTC/NNRTI) to abacavir, lamivudine and dolutegravir (A...See full text at original site
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引用元：
https://doi.org/10.1111/hiv.13215

データ提供：米国国立医学図書館（NLM）

Bone Health in Transition: Switching Antiretroviral Regimens

In the ongoing fight against HIV, researchers are constantly seeking optimal treatment strategies that balance effectiveness and safety. This study investigates the impact of switching from a tenofovir-based antiretroviral regimen to an abacavir-based regimen on bone mineral density (BMD) in women living with HIV. Their findings suggest that switching regimens can have a positive effect on bone health, offering hope for those seeking to improve their bone density while maintaining effective HIV treatment.

Bone Density Gains: A Positive Shift in Regimen

The study reveals that women who switched from a tenofovir-based regimen to an abacavir-based regimen experienced improvements in bone mineral density. While the specific magnitude of these gains may vary, this finding is encouraging for individuals concerned about the potential bone-related side effects of tenofovir.

Navigating Treatment Options: A Balancing Act for Bone Health

This study highlights the importance of considering bone health when choosing and managing antiretroviral regimens. While the abacavir-based regimen appears to be associated with positive changes in bone density, regular monitoring of bone health is crucial to ensure the optimal well-being of individuals living with HIV.

Dr.Camel's Conclusion

The journey of HIV treatment is a continuous quest for the best possible care. This study sheds light on the potential benefits of switching to an abacavir-based regimen for bone health. It's a reminder that we must always strive to find the right balance between effectiveness and safety in treating this complex condition. Just like a camel adapting to the changing desert landscape, we must adapt our treatment strategies to ensure the optimal health of individuals living with HIV.

Date :
  1. Date Completed 2022-03-14
  2. Date Revised 2022-03-14
Further Info :

Pubmed ID

34866304

DOI: Digital Object Identifier

10.1111/hiv.13215

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PICO Info
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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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