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The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique.

Author: GengXiao-Nan, GouKai-Feng, QiuXiang-Jun, SuYan-Ding, WangHui-Jun, ZhouChun-Yan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study developed a new UPLC-MS/MS technique for determining ripretinib concentration in beagle dog plasma. It found that itraconazole and voriconazole can inhibit ripretinib metabolism, increasing its plasma exposure. These findings may have implications for ripretinib use in humans.
Paper Details　
Original Abstract of the Article :
BACKGROUND: A new UPLC-MS/MS technique for the determination of ripretinib in beagle dog plasma was developed, and the pharmacokinetic effects of voriconazole and itraconazole on ripretinib in beagle dogs were studied. METHODS: After extraction with ethyl acetate under alkaline conditions, ripretin...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643159/

データ提供：米国国立医学図書館（NLM）

Pharmacokinetic Effects of Antifungal Drugs on Ripretinib: A Canine Perspective

This study investigates the pharmacokinetic interactions between ripretinib, a cancer drug, and two common antifungal medications, itraconazole and voriconazole, in beagle dogs.

Understanding Drug Interactions: A Canine Case Study

The researchers developed a precise UPLC-MS/MS technique to measure the levels of ripretinib in beagle dog plasma. They then studied the effects of itraconazole and voriconazole on ripretinib's pharmacokinetics.

Key Findings and Drug Interactions

The study revealed that both itraconazole and voriconazole significantly increased the plasma exposure of ripretinib in beagle dogs, indicating potential drug interactions.

Health Implications and Treatment Considerations

These findings highlight the importance of carefully considering potential drug interactions, especially when combining ripretinib with antifungal medications. Further research is needed to understand the implications for human patients.

Dr.Camel's Conclusion

Imagine a desert landscape where two different plant species compete for the same resources. This study investigates how two drugs interact in a canine model, revealing potential for competition and altered drug activity. It emphasizes the need for careful monitoring of drug interactions in clinical settings.
Date :
  1. Date Completed 2022-03-02
  2. Date Revised 2023-12-04
Further Info :

Pubmed ID

34876808

DOI: Digital Object Identifier

PMC8643159

Related Literature

Article Analysis
・Effects of ripretinib
SNS
PICO Info
in preparation
Languages

English

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