Toxic Effects of High-dose Meloxicam and Carprofen on Female CD1 Mice.

Meloxicam and Carprofen: Navigating the Desert of Safety and Efficacy in Mice

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to manage pain and inflammation, but their use in research animals often requires careful consideration of their potential side effects. This study investigates the safety of two commonly used NSAIDs, meloxicam and carprofen, in mice, focusing on potential renal and gastrointestinal toxicity.

Meloxicam and Carprofen: A Quest for Safety and Efficacy

The researchers administered high doses of meloxicam and carprofen to female CD-1 mice for varying durations. They assessed potential toxicity by evaluating serum chemistry profiles, fecal occult blood, and histopathological changes in tissues. The study found that meloxicam, when administered at a high dose of 20 mg/kg, caused gastric toxicity in mice treated for 3 or 7 days.

Meloxicam and Carprofen: A Quest for Safety and Efficacy

In contrast, carprofen at the same dose appeared to have minimal toxic effects on the parameters measured. This suggests that carprofen may be a safer option for managing pain and inflammation in mice, particularly when higher doses are required. However, the study also highlights the importance of considering the duration of treatment when using NSAIDs, as prolonged exposure can increase the risk of side effects.

Dr. Camel's Conclusion

This research provides valuable insights into the safety of meloxicam and carprofen in mice, two commonly used NSAIDs. The study's findings highlight the importance of considering potential side effects, particularly gastric toxicity, when using meloxicam in mice. The research also suggests that carprofen may be a safer alternative for managing pain and inflammation in mice, but further research is needed to confirm these findings.