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Evidence of feedback regulation of C-type natriuretic peptide during Vosoritide therapy in Achondroplasia.

Author: BacinoCarlos, ChanMing Liang, DayJonathan R S, EspinerEric A, FishelevaElena, IrvingMelita, JehaGeorge S, LarimoreKevin, PhillipsJohn A, PrickettTimothy C R, SavarirayanRavi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Endogenous CNP production was assessed in children with achondroplasia receiving vosoritide over a 5-year period. Plasma NTproCNP levels were initially elevated and decreased significantly within the first 3 months of treatment. These findings suggest that CNP production is regulated during vosoritide treatment and that CNP levels may be influenced by both direct and indirect feedback mechanisms.
Paper Details　
Original Abstract of the Article :
Evidence from genetic disorders of CNP signalling suggests that plasma concentrations of CNP are subject to feedback regulation. In subjects with Achondroplasia (Ach), CNP intracellular activity is suppressed and plasma concentrations are raised but the therapeutic impact of exogenous CNP agonists o...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688426/

データ提供：米国国立医学図書館（NLM）

Vosoritide Therapy and CNP Regulation in Achondroplasia: A Journey Through Growth and Development

Achondroplasia, a genetic disorder that affects bone growth, is like a desert landscape where the landscape is forever altered, hindering the natural processes of development. This study explores the impact of vosoritide therapy, a treatment for achondroplasia, on the regulation of C-type natriuretic peptide (CNP), a crucial hormone involved in bone growth. The researchers, like patient explorers navigating a challenging terrain, sought to understand the intricate relationship between this therapy and CNP levels.

Vosoritide’s Impact on CNP Regulation: A Detailed Examination

This research, like a detailed map of a desert ecosystem, meticulously examines the effects of vosoritide therapy on CNP regulation. The study found that vosoritide therapy significantly reduces CNP levels in children with achondroplasia, suggesting that the therapy itself may influence CNP production. This discovery, like finding a hidden oasis within a parched desert, offers valuable insights into the mechanisms underlying the effectiveness of vosoritide therapy.

A Promising Avenue for Bone Growth in Achondroplasia: A Glimmer of Hope

This research, like a beacon of hope illuminating a challenging path, highlights the potential of vosoritide therapy to influence CNP levels and promote bone growth in children with achondroplasia. The study’s findings offer a glimmer of hope for individuals with this condition, providing a promising avenue for future research and development of targeted therapies.

Dr.Camel's Conclusion

This research, like a journey through a shifting desert landscape, explores the intricate relationship between vosoritide therapy and CNP regulation in achondroplasia. The study’s findings, like a precious oasis in a barren desert, offer valuable insights into the potential of this therapy to promote bone growth, providing hope for a brighter future for individuals with this condition.

Date :
  1. Date Completed 2022-02-25
  2. Date Revised 2022-02-25
Further Info :

Pubmed ID

34930956

DOI: Digital Object Identifier

PMC8688426

Related Literature

Article Analysis
・Effects of vosoritide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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