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Pharmacophore-guided Virtual Screening to Identify New β<sub>3</sub> -adrenergic Receptor Agonists.
Author: HamSeungmin, HutchinsonDana Sabine, NagiriChisae, NurekiOsamu, SchusterDaniela, ShihoyaWataru, UjiantariNavista Sri Octa
Original Abstract of the Article :
The β<sub>3</sub> -adrenergic receptor (β<sub>3</sub> -AR) is found in several tissues such as adipose tissue and urinary bladder. It is a therapeutic target because it plays a role in thermogenesis, lipolysis, and bladder relaxation. Two β<sub>3</sub> -AR agonists are used clinically...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400856/
データ提供：米国国立医学図書館（NLM）
Virtual Screening for New Beta3-Adrenergic Receptor Agonists: Unlocking the Potential of a Key Target
The beta3-adrenergic receptor (beta3-AR), a key player in several bodily processes, is a promising therapeutic target. It plays a crucial role in thermogenesis, fat breakdown, and bladder relaxation, making it relevant for treating various conditions. Currently, there are two beta3-AR agonists used clinically, but they have side effects, including increased blood pressure. This study explores the potential of virtual screening, a powerful tool for identifying new drug candidates, to uncover promising beta3-AR agonists. The researchers developed a pharmacophore model, a representation of the essential features of a molecule required for activity, and used it to screen a virtual library of compounds. They then evaluated the biological activity of the virtual hits through in vitro assays, confirming the activity of several compounds.
Virtual Screening: A Powerful Tool in Drug Discovery
The research demonstrates the effectiveness of virtual screening in identifying potential drug candidates, highlighting its value in expediting the drug discovery process. The study's successful identification of several novel beta3-AR agonists highlights the potential of this approach for developing new therapies with fewer side effects.
The Future of Beta3-AR Agonists: A Journey of Discovery
This research holds exciting implications for the future of beta3-AR agonists. The discovery of new, potentially safer, beta3-AR agonists could lead to improved treatments for a wide range of conditions. This research emphasizes the importance of innovative approaches, such as virtual screening, to accelerate the development of new and effective therapies.
Dr.Camel's Conclusion
This study showcases the potential of virtual screening for identifying new beta3-AR agonists, a crucial step in developing new therapies for a variety of conditions. The researchers successfully validated their pharmacophore model and identified several promising drug candidates, opening new avenues for research and development. I am optimistic that these findings will lead to the development of safer and more effective beta3-AR agonists, improving the lives of many.
Date :
- Date Completed 2022-07-12
- Date Revised 2022-08-27
Further Info :
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