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Tyrosine kinase inhibitors in breast cancer (Review).

Author: BadiuCristinel Dumitru, CosteaDaniel Ovidiu, IancuGeorge, IancuRaluca, SerbanDragos, TanasescuCiprian, TudorCorneliu, TudosieMihai Silviu, VasileDanut, ZguraAnca

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Anti-EGFR therapy has shown promise in breast cancer treatment, but most researched agents lack specificity and have frequent side effects. Tyrosine kinase inhibitors (TKIs) have advantages, including reduced cardiotoxicity and oral administration. Lapatinib, neratinib, and pyrotinib are the only TKIs approved for limited indications in a subset of breast cancer patients. Future research should focus on identifying breast cancer subtypes and developing more targeted agents to improve treatment outcomes.
Paper Details　
Original Abstract of the Article :
Anti-epidermal growth factor receptor (EGFR)-targeted therapy has been intensely researched in the last years, motivated by the favorable results obtained with monoclonal antibodies in HER2-enriched breast cancer (BC) patients. Most researched alternatives of anti-EGFR agents were tyrosine kinase in...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713180/

データ提供：米国国立医学図書館（NLM）

Tyrosine Kinase Inhibitors in Breast Cancer

This research delves into the complex world of breast cancer treatment, exploring the role of tyrosine kinase inhibitors (TKIs) in targeting specific pathways involved in tumor growth. It's like navigating a treacherous desert landscape of cancer biology, searching for effective weapons to combat this disease.

The study reviews the research on TKIs in breast cancer, highlighting their potential benefits and limitations. It emphasizes the importance of identifying specific breast cancer subtypes and developing targeted therapies that are effective and safe. It's like uncovering a map of hidden pathways in the desert of breast cancer, leading to more precise and effective treatments.

Targeted Therapies: A Promising Approach for Breast Cancer

This study underscores the promise of targeted therapies in breast cancer. It's like finding a hidden oasis of hope in the vast desert of cancer treatment, offering new strategies to combat this challenging disease.

Implications for Health and Lifestyle

This research highlights the importance of personalized medicine in breast cancer treatment. It's like learning to navigate the unique landscape of each patient's disease, tailoring treatment strategies for optimal outcomes. Further research is needed to develop even more effective and targeted therapies for breast cancer.

Dr.Camel's Conclusion

Breast cancer is a complex and challenging disease, but research continues to provide new insights and potential treatments. This study is a reminder that we must keep exploring the desert of cancer biology, seeking new oases of knowledge and innovation to improve the lives of patients.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-01-01
Further Info :

Pubmed ID

34970337

DOI: Digital Object Identifier

PMC8713180

SNS
PICO Info
in preparation
Languages

English

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