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Efficacy and safety of esketamine nasal spray by sex in patients with treatment-resistant depression: findings from short-term randomized, controlled trials.

Author: CanusoCarla M, CooperKimberly, DalyElla J, FreemanMarlene P, JonesRobyn R, KornsteinSusan G, NicholsonSusan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This post hoc analysis of three randomized, controlled studies evaluated the efficacy and safety of esketamine for treatment-resistant depression (TRD) in women and men. The analysis showed no significant sex differences in antidepressant efficacy or safety.
Paper Details　
Original Abstract of the Article :
The objective of this analysis was to determine if there are sex differences with esketamine for treatment-resistant depression (TRD). Post hoc analyses of three randomized, controlled studies of esketamine in patients with TRD (TRANSFORM-1, TRANSFORM-2 [18-64 years], TRANSFORM-3 [≥ 65 years]) were ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921149/

データ提供：米国国立医学図書館（NLM）

Esketamine: Navigating the Dunes of Treatment-Resistant Depression

The journey through treatment-resistant depression (TRD) can feel like traversing a vast and unforgiving desert. This study delves into the potential of esketamine nasal spray as a new treatment option for those struggling with this challenging condition. The researchers analyzed data from three randomized, controlled trials, focusing on potential sex differences in the efficacy and safety of esketamine. Their analysis revealed that esketamine nasal spray, when combined with a newly initiated oral antidepressant, demonstrated similar antidepressant efficacy and safety in both women and men with TRD. This research offers hope for individuals battling TRD, suggesting that esketamine may provide a new path towards recovery for both genders.

Esketamine: A New Oasis in the Desert of Treatment-Resistant Depression

This research provides a glimmer of hope for those struggling with TRD. The findings suggest that esketamine nasal spray, in combination with oral antidepressants, may offer a new oasis of healing for both women and men. The study's findings highlight the potential of esketamine as a valuable addition to the therapeutic landscape for TRD.

Navigating the Side Effects: A Cautious Approach

While the study suggests that esketamine offers promise for those with TRD, it is crucial to remain aware of potential side effects. The researchers noted that some adverse events, like nausea and dizziness, were reported more frequently in women than men. This underscores the need to navigate the use of esketamine cautiously, considering individual patient characteristics and potential risks.

Dr.Camel's Conclusion

This study offers a hopeful glimpse into the potential of esketamine nasal spray for treating TRD. While the journey through this challenging condition can be arduous, esketamine offers a potential path towards recovery for both women and men. However, it is essential to approach esketamine treatment with careful consideration and a watchful eye for any potential side effects.

Date :
  1. Date Completed 2022-03-24
  2. Date Revised 2023-02-10
Further Info :

Pubmed ID

34973081

DOI: Digital Object Identifier

PMC8921149

Related Literature

Article Analysis
・Effects of esketamine nasal spray
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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